Forced normalization after turning off vagus nerve stimulation in Lennox–Gastaut syndrome

Sydney Lee; Alyssa Denton; Lady Diana Ladino; Karen Waterhouse; Aleksander Vitali; Jose Francisco Tellez-Zenteno

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Forced normalization after turning off vagus nerve stimulation in Lennox–Gastaut syndrome

机译：Lennox–Gastaut综合征关闭迷走神经刺激后强制归一化

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Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped.The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy.The patient had multiple types of seizures including drop attacks, absences, and tonic–clonic seizures. He tried vagus nerve stimulation for two years without success. Forced normalization developed after the vagus nerve stimulator was turned off.This is the first case to our knowledge to describe forced normalization after turning off the vagus nerve stimulator.

机译：强迫正常化是癫痫发作缓解患者的精神症状的发展。我们介绍了1例Lennox Gastaut综合征，该病在迷走神经刺激停止后出现了强制正常化。该患者患有耐药性癫痫和抗癫痫药失败，迷走神经刺激和部分切开术。该患者有多种癫痫发作类型，包括跌落发作，失神和强直-阵挛性癫痫发作。他尝试迷走神经刺激了两年，但没有成功。迷走神经刺激器关闭后出现强制归一化。这是我们所知的第一个描述关闭迷走神经刺激器后强制归一化的案例。

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《Epilepsy & Behavior Case Reports》 |2019年第1期|共3页
作者
Sydney Lee; Alyssa Denton; Lady Diana Ladino; Karen Waterhouse; Aleksander Vitali; Jose Francisco Tellez-Zenteno;
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中图分类神经病学与精神病学;
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Forced normalizationLennox Gastaut syndromeVagus nerve stimulation;

机译：强迫正常化Lennox Gastaut综合征迷走神经刺激;

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1. Long-term outcome after callosotomy or vagus nerve stimulation in consecutive prospective cohorts of children with Lennox-Gastaut or Lennox-like syndrome and non-specific MRI findings [J] . CukiertA., CukiertC.M., BurattiniJ.A., Seizure: the journal of the British Epilepsy Association . 2013,第5期

机译：Lennox-Gastaut或Lennox样综合征和非特异性MRI表现的儿童的连续预期队列中，在切开血管或迷走神经刺激后的长期结局
2. Improved seizure control and regaining cognitive milestones after vagus nerve stimulation revision surgery in Lennox–Gastaut syndrome [J] . Hilde M. Braakman, Joke Creemers, Danny M. Hilkman, Epilepsy & Behavior Case Reports . 2018,第2期

机译：Lennox–Gastaut综合征迷走神经刺激翻修手术后癫痫发作控制得到改善并恢复了认知里程碑
3. An Observational Report of Worsening Seizures with Increase in Total Charge Delivered Per Day by Vagus Nerve Stimulation in 4 Patients with Lennox-Gastaut Syndrome [J] . Narayanan Jaishree Brain stimulation . 2016,第2期

机译：4例Lennox-Gastaut综合征患者因迷走神经刺激导致癫痫发作加剧，每日总电荷增加的观察报告
4. Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method [C] . Cho Jae-Hyun, Jung Young-Jin, Kang Hoon-Chul, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：使用定向传递函数法定位Lennox-Gastaut综合征的发作期区域
5. Effects of Sub-Perceptual Vagus Nerve Stimulation on Brain Activity Measured Intra-Cranially in Humans [D] . Zi, Yihan. 2020

机译：患有透过迷宫神经刺激对人类肿声中脑活动的影响
6. Forced normalization after turning off vagus nerve stimulation in Lennox–Gastaut syndrome [O] . Sydney Lee, Alyssa Denton, Lady Diana Ladino, 2019

机译：Lennox–Gastaut综合征关闭迷走神经刺激后的强制归一化
7. Long-term outcome after callosotomy or vagus nerve stimulation in consecutive prospective cohorts of children with Lennox–Gastaut or Lennox-like syndrome and non-specific MRI findings [O] . Cukiert Arthur, Cukiert Cristine M., Burattini Jose A., 2013

机译：Lennox–Gastaut或Lennox综合征和非特异性MRI表现的儿童的连续前瞻性队列中，在切开血管或迷走神经刺激后的长期结果

Forced normalization after turning off vagus nerve stimulation in Lennox–Gastaut syndrome

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