R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy

Jeanne T. Paz; John R. Huguenard

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R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy

机译：你还行吗？ R通道在癫痫中的新型治疗潜力。

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Finally, this study leads to the idea that targeting R channels could be a novel therapeutic approach, potentially useful in cases where absence epilepsy is refractory to conventional antiepileptic medications. Indeed, combining R-channel blockers with T-channel blockers would have a synergistic effect on thalamic burst firing and might increase the efficacy over current antiepileptic monotherapies.

机译：最后，这项研究导致了这样一个想法，即靶向R通道可能是一种新颖的治疗方法，在失神癫痫症对常规抗癫痫药物难以治愈的情况下可能有用。的确，将R通道阻滞剂与T通道阻滞剂组合使用将对丘脑爆发放电产生协同作用，并且可能会增加目前抗癫痫单一疗法的疗效。

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《Epilepsy currents》 |2012年第2期|共页
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Jeanne T. Paz; John R. Huguenard;
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中图分类神经病学与精神病学;
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R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy

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