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首页> 外文期刊>Emerging Health Threats Journal >Human enterovirus 71 epidemics: what’s next?
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Human enterovirus 71 epidemics: what’s next?

机译：人类肠道病毒71种流行病：下一步是什么？

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Human enterovirus 71 (EV71) epidemics have affected various countries in the past 40 years. EV71 commonly causes hand, foot and mouth disease (HFMD) in children, but can result in neurological and cardiorespiratory complications in severe cases. Genotypic changes of EV71 have been observed in different places over time, with the emergence of novel genotypes or subgenotypes giving rise to serious outbreaks. Since the late 1990s, intra- and inter-typic recombination events in EV71 have been increasingly reported in the Asia-Pacific region. In particular, ‘double-recombinant’ EV71 strains belonging to a novel genotype D have been predominant in mainland China and Hong Kong over the last decade, though co-circulating with a minority of other EV71 subgenotypes and coxsackie A viruses. Continuous surveillance and genome studies are important to detect potential novel mutants or recombinants in the near future. Rapid and sensitive molecular detection of EV71 is of paramount importance in anticipating and combating EV71 outbreaks.
机译：在过去的40年中，人类肠道病毒71（EV71）流行已影响到各个国家。 EV71通常会导致儿童手足口病（HFMD），但在严重的情况下可能会导致神经系统和心肺系统并发症。随着时间的推移，已经在不同的地方观察到了EV71的基因型变化，新基因型或亚基因型的出现引起了严重的暴发。自1990年代后期以来，在亚太地区越来越多地报道了EV71型内和型间重组事件。尤其是，在过去的十年中，尽管与少数其他EV71亚型和柯萨奇A型病毒共同传播，但属于新基因型D的“双重组” EV71株在中国大陆和香港占主导地位。持续的监测和基因组研究对于在不久的将来检测潜在的新型突变体或重组体至关重要。对EV71进行快速灵敏的分子检测对于预测和抵抗EV71的爆发至关重要。

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