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首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.
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Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

机译：含氢乙醇提取物和含羞草（Wimd。Poir）树皮级分的抗炎和抗氧化活性。

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This study investigated the antioxidant and anti-inflammatory effects from the inner bark of Mimosa tenuiflora. The hydroethanol extract (HEE) and its hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fractions were prepared and submitted to phytochemical screening and antioxidant activity. In vivo anti-inflammatory effect was investigated by using 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema and myeloperoxidase (MPO) activity in mice ears. Phytochemical prospection of HEE revealed the presence of flavonoids, tannins, xantones, triterpenes, esteroids and phenols. Higher total phenol content was found in EAF and higher percentages of inhibition of 2,2-diphenyl-1-picrylhydrazyl free DPPH radical were found for HEE, EAF or HMF. Lipid peroxidation (LP) induced by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) was greatly inhibited by HEE or EAF, while inhibition of FeSO4 - induced LP was higher for HMF. The coadministration of HEE (1?or?3?mg/ear) decreased edema (p<0.001) and MPO activity (p<0.05). All fractions reduced mice ear edema at the same extent, however, while EAF and HMF reduced MPO activity in mice ear at both 1 and 3?mg/ear (p<0.001 and p<0.05 respectively), CLF only at 3?mg/ear (p<0.05) and HXF did not affect this parameter. Taken together, these results demonstrate that inner bark of M. tenuifolia possesses antioxidant and anti-inflammatory effects.
机译：这项研究调查了含羞草内皮的抗氧化和抗炎作用。制备了氢乙醇提取物（HEE）及其己烷（HXF），氯仿（CLF），乙酸乙酯（EAF）和氢甲醇（HMF）馏分，并进行了植物化学筛选和抗氧化活性。通过在小鼠耳朵中使用12-O-十四烷酰佛波醇13-乙酸盐（TPA）诱导的水肿和髓过氧化物酶（MPO）活性研究了体内抗炎作用。 HEE的植物化学前景揭示了类黄酮，单宁，黄酮，三萜，类固醇和酚的存在。在EAF中发现较高的总酚含量，而对HEE，EAF或HMF发现2，2-二苯基-1-吡啶并肼基游离DPPH自由基的抑制百分比更高。 HEE或EAF极大地抑制了2,2'-偶氮双（2-prop基丙烷）二盐酸盐（AAPH）诱导的脂质过氧化（LP），而对于HMF，FeSO4诱导的LP的抑制作用更高。 HEE（1？或？3？mg /耳）的共同给药减少了水肿（p <0.001）和MPO活性（p <0.05）。所有分数均以相同的程度减轻小鼠耳部水肿，然而，EAF和HMF分别以1和3？mg / ear（分别为p <0.001和p <0.05）降低小鼠耳中的MPO活性，CLF仅以3？mg / ear降低。耳朵（p <0.05）和HXF不会影响此参数。综上所述，这些结果表明藤蔓分枝杆菌的内部树皮具有抗氧化和抗炎作用。

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