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首页> 外文期刊>European Cells & Materials >Biomaterials for intervertebral disc regeneration: past performance and possible future strategies
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Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

机译：椎间盘再生的生物材料：过去的表现和可能的未来策略

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.
机译：椎间盘退变与大多数颈椎和腰椎病相关，其中慢性下腰痛已成为导致质量调整寿命降低的首要原因。在寻找当前不太理想且通常是高侵入性治疗的替代方案时，正在设计再生策略，但这些策略尚未达到临床实践。策略包括使用干细胞，基因疗法，生长因子和生物材料载体。生物材料载体是肌肉骨骼再生医学技术的重要组成部分。来自天然和合成来源的几种生物材料已经用于体外和体内IVD的再生。易用性，机械性能，再生能力及其作为再生和抗变性因子载体的适用性等方面决定了它们是否适合IVD再生。本篇综述就这些特性，包括其缺点，对使用的生物材料进行了概述。另外，由于迄今为止生物材料的应用似乎仅基于可获得性和直觉的结合，因此提出了一种更合理的设计，以供将来将生物材料用于IVD再生。理想情况下，使用高通量筛选来鉴定最佳有效材料，或者应该进行中等含量的比较研究，以确定适合将来用于新型材料研究的参考材料。

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