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首页> 外文期刊>European Chemical Bulletin >Ethyl linalool and diethyl phthalate from Pycnanthus angolensis (Welw.) Warb.
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Ethyl linalool and diethyl phthalate from Pycnanthus angolensis (Welw.) Warb.

机译：碧萝ant（Pycnanthus angolensis）的乙基芳樟醇和邻苯二甲酸二乙酯。

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Pycnanthus angolensis (Welw.) Warb . belongs to the family, Myristiceae. Extracts of the plant are used in African ethno-medicine to treat diabetes, lumbago, wounds, arthritis, anemia, mouth-thrush, scabies, infertility and skin-fungal infections amongst many others. Flavonoids, terpenes, fatty acid derivatives and quinones had previously been isolated from different organs of the plant. Before now, very scanty literature exits on organic fractions from where specific compounds had been obtained. Hence, the chemical and biological parameters of the ethyl acetate fraction were studied. The leaves were to be extracted cold with 50 % ethanol and the obtained aqueous crude extract partitioned with ethyl acetate. Furthermore, the ethyl acetate fraction was to be subjected to silica gel column chromatography and the isolated chemical compounds tested for antimicrobial activity. Methodology: The chemical structures of compounds so obtained from the silica-gel column chromatography of the ethyl acetate fraction were to be elucidated and analyzed for antimicrobial activities using the hole-in agar diffusion technique using the microbes namely, Staphylococcus aureus , Escherichia coli and Candida albicans . Results: Two isolates coded NG-2 (pale yellow compound; 62 mg; R f . (0.53);[α] D 20 (+3o); [n] D 20 (1.4009) and NG-4c (off-white compound; 36 mg, R f (0.24); [α] D 20 (0o); [n] D 20 (1.5006) whose identities have been revealed to be 3-ethoxy-3, 7-dimethyl-1, 6-octadiene (ethyl linalool) and diethyl phthalate (1, 2-benzenedicarboxylic acid diethyl ester) respectively using the MS and IR spectral techniques. Both NG-2 and NG-4c were strongly bacteriostatic against E. coli , but recorded no activity against S. aureus and C. albicans . Conclusion : The isolation of the two compounds is being reported for the first time from the ethyl acetate fraction of the plant. Hence, NG-2 and NG-4c would serve as chemotaxonomic markers for this species and the genus, Pycnanthus in general. Also, the results of the antimicrobial screening partially lends some justification to its use especially in the treatment /management of bacterial disease.
机译：Pycnanthus angolensis（Welw。）Warb。属于肉豆蔻科。该植物的提取物被用于非洲民族药物中，以治疗糖尿病，腰痛，伤口，关节炎，贫血，鹅口疮，sc疮，不孕症和皮肤真菌感染等。类黄酮，萜烯，脂肪酸衍生物和醌以前是从植物的不同器官中分离出来的。在此之前，关于有机馏分的文献很少，而有机馏分是从中获得特定化合物的。因此，研究了乙酸乙酯级分的化学和生物学参数。将叶子用50％乙醇冷提取，并将获得的含水粗提取物用乙酸乙酯分配。此外，将乙酸乙酯级分进行硅胶柱色谱，并测试分离的化合物的抗微生物活性。方法：将从乙酸乙酯级分的硅胶柱色谱中获得的化合物的化学结构进行阐明，并使用金黄色葡萄球菌，大肠杆菌和念珠菌等微生物，采用孔琼脂扩散技术分析其抗菌活性。白色的。结果：两个分离株编码为NG-2（浅黄色化合物; 62 mg; R f（0.53）; [α] D 20（+ 3o）; [n] D 20（1.4009）和NG-4c（灰白色化合物） ; 36 mg，R f（0.24）; [α] D 20（0o）; [n] D 20（1.5006）的身份被证明是3-乙氧基-3，7-二甲基-1，6-辛二烯（分别使用MS和IR光谱技术检测NG-2和NG-4c对大肠杆菌的强烈抑菌作用，但对金黄色葡萄球菌和S.Aureus没有活性。结论：首次从植物的乙酸乙酯级分中分离出两种化合物，因此NG-2和NG-4c可以作为该物种以及碧萝属的化学分类标记。同样，抗微生物筛选的结果部分地为其使用特别是在细菌疾病的治疗/管理中提供了一些理由。

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