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首页> 外文期刊>European Journal of General Medicine >Comparison Of Different Agents On Radiographic Contrast Agent Induced Nephropathy
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Comparison Of Different Agents On Radiographic Contrast Agent Induced Nephropathy

机译：射线造影剂诱发肾病中不同药物的比较

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Aim: Nephropathy induced by contrast media (CM) still a problem in clinical practice and a variety of therapeutic interventions have been used in an attempt to prevent radiocontrast-induced nephropathy. However most of the published reports are placebo controlled studies and especially in patients with pre-existing renal insufficiency. Therefore, in this study we wanted to investigate and to compare the efficacy of not only one agent, but also N-acetylcysteine, theophylline, nifedipine and misoprostol in the prevention of RCIN in subjects without renal insufficiency. Methods: We studied 97 non-diabetic patients without pre-existing renal insufficiency who received 100 ml low osmolar CM, Iomeprol or Iopamidol. Patients were randomized to five groups; Group S; only saline hydration (SH) used control group, group N; SH plus N-acetylcysteine, group M; SH plus misoprostol, Group N; SH plus nifedipine and Group T; SH plus theophylline. Patients were treated for three days and received 2000 ml saline i.v. each day. Serum creatinine and creatinine clearance were measured before and three days after CM application. Results: We were able to observe RCIN in four patients in group T and one patient in group NAC. Serum creatinine level increased after administration of radiocontrast agent in group M and T. Conclusion: We did not only observe any no additional advantage in administration of N-acetylcysteine (NAC), theophylline, nifedipine and misoprostol to SH alone in the prevention of RCIN but also an adverse effect of theophylline. Therefore, further studies with much more patients were included are necessary.
机译：目的：造影剂（CM）诱发的肾病在临床实践中仍然是一个问题，并且已经采取了多种治疗干预措施来预防放射性造影剂诱发的肾病。但是，大多数已发表的报告都是安慰剂对照研究，尤其是对于已有肾功能不全的患者。因此，在这项研究中，我们想要研究和比较不仅是一种药物，而且是N-乙酰半胱氨酸，茶碱，硝苯地平和米索前列醇在没有肾功能不全的受试者中预防RCIN的功效。方法：我们研究了97例无糖尿病，无肾功能不全的非糖尿病患者，他们接受了100毫升低渗透压的CM，艾美普尔或Iopamidol。患者被随机分为五组。 S组;对照组仅使用生理盐水（SH），N组; SH加N-乙酰半胱氨酸，M组; SH加米索前列醇，N组; SH加硝苯地平和T组; SH加茶碱。患者接受了三天的治疗，并接受了2000 ml生理盐水。每天。在应用CM之前和之后三天测量血清肌酐和肌酐清除率。结果：我们能够在T组的4例患者和NAC组的1例患者中观察RCIN。在M和T组中，在给予放射性对比剂后，血清肌酐水平升高。结论：我们不仅观察到单独给SH服用N-乙酰半胱氨酸（NAC），茶碱，硝苯地平和米索前列醇在预防RCIN方面没有任何其他优势，而且也是茶碱的不良反应。因此，有必要对更多患者进行进一步研究。

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