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首页> 外文期刊>European Journal of Histochemistry >Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells
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Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells

机译：胸腺素β4在正常皮肤，结肠粘膜和肿瘤浸润肥大细胞中的表达

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摘要

Mast cells (MCs) are metachromatic cells that originate from multipotential hemopoietic stem cells in the bone marrow. Two distinct populations of MCs have been characterized: mucosal MCs are tryptase-positive while mast cells in skin contain tryptase and chymase. We now show that a sub-population of MCs is highly immunoreactive for thymosin β4, as revealed by immunohistochemical analyses of normal skin, normal colon mucosa and salivary gland tumors. Four consecutive serial sections from each case were immunostained for thymosin β4 (Tβ4), chymase, tryptase and stained for toluidine blue. In skin biopsies, MCs showed a comparable immunoreactivity for Tβ4, chymase and tryptase. In normal colon mucosa the vast majority of mucosal MCs expressed a strong cytoplasmic immunoreactivity for tryptase and for Tβ4, in the absence of chymase reactivity. A robust expression of Tβ4 was detected in tumor-infiltrating and peritumoral mast cells in salivary gland tumors and breast ductal infiltrating carcinomas. Tumor-infiltrating MCs also showed a strong immunoreactivity for chymase and tryptase. In this paper, we first demonstrate that normal dermal and mucosal mast cells exhibit strong expression of thymosin β4, which could be considered a new marker for the identification of mast cells in skin biopsies as well as in human tumors. The possible relationship between the degree of Tβ4 expression in tumor-infiltrating mast cells and tumor behaviour warrants further consideration in future investigations.
机译：肥大细胞（MCs）是起源于骨髓中的多能造血干细胞的变色细胞。已经表征了两个不同的MC人群：粘膜MC为类胰蛋白酶阳性，而皮肤中的肥大细胞含有类胰蛋白酶和糜酶。现在我们显示，如正常皮肤，正常结肠粘膜和唾液腺肿瘤的免疫组织化学分析所揭示，MC的亚群对胸腺素β4具有高度免疫反应性。每个病例的四个连续连续切片均进行胸腺素β4（Tβ4），糜蛋白酶，类胰蛋白酶的免疫染色，并进行甲苯胺蓝染色。在皮肤活检中，MC对Tβ4，糜蛋白酶和类胰蛋白酶显示出相当的免疫反应性。在正常结肠粘膜中，在没有糜酶反应性的情况下，绝大多数的粘膜MC对类胰蛋白酶和Tβ4表达强的细胞质免疫反应性。在唾液腺肿瘤和乳腺导管浸润癌中，在肿瘤浸润和肿瘤周围肥大细胞中检测到了Tβ4的强表达。肿瘤浸润MCs还显示出针对糜酶和类胰蛋白酶的强免疫反应性。在本文中，我们首先证明正常的皮肤和粘膜肥大细胞表现出强烈的胸腺素β4表达，这可被认为是鉴定皮肤活检以及人类肿瘤中肥大细胞的新标记。肿瘤浸润肥大细胞中Tβ4表达程度与肿瘤行为之间的可能关系值得在未来研究中进一步考虑。

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