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首页> 外文期刊>European Journal of Medicinal Plants >In-vitro Evaluation of Antioxidant Potency of Organic Extracts of Leaves of Corchorus depressus Linn.
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In-vitro Evaluation of Antioxidant Potency of Organic Extracts of Leaves of Corchorus depressus Linn.

机译：Corcorrus depressus Linn叶片有机提取物的抗氧化能力的体外评估。

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Aim: Evaluation of free radical scavenging and lipid peroxidation inhibitory activities of commercially available leaves of Corchorus depressus Linn. by in-vitro chemical analysis. Methodology: Four different solvent extracts methanol-CDM, ethanol-CDE, ethyl acetate-CDEA and hexane-CDH were studied for their free radical scavenging activities using 1-diphenyl-2-picrylhydrazyl (DPPH) radical assay method and the results were expressed as SC50 values. The lipid peroxidation inhibitory activities of three different concentrations (0.1, 0.5 and 1.0 mg/mL) were evaluated using b-carotene-linoleic acid model system and the results were expressed as oxidation rate ratio (ROR), antioxidant activity (AA) and antioxidant activity coefficient (CAA). L-Ascorbic acid-AA, a-tocopherol-TOC and BHT were used as reference compounds. The total polyphenol contents of these extracts were also determined using Folin-Ciocalteau reagent. Results: The total polyphenol contents of extracts were decreased in the order of: CDM > CDE > CDEA CDH. In DPPH radical assay, CDM exhibited higher free radical scavenging activity (SC50: 216.27 μg/mL) than CDE (327.84 μg/mL) and CDEA (544.28 μg/mL). In comparison with natural antioxidants AA and TOC, the overall ranking was decreased in the order of: AA > CDM > TOC > CDE > CDEA CDH. In b-carotene-linoleic acid model system, CDM also exhibited higher protective activity against lipid peroxidation than other extracts as it exhibited lower ROR (0.4903 to 0.2752) and higher AA (50.96 to 72.47) and CAA (280.58 to 513.13) respectively amongst the studied extract. In comparison with BHT and TOC, CDM exhibited promising potency than TOC. Amongst the studied concentration 0.5 and 1.0 mg/mL were the mostly potent antioxidant against oxidation of linoleic acid. Conclusion: CDM exhibited most propitious antioxidant activities irrespective of the method undertaken in this study. CDM and CDE had protective activity against oxidation of fatty acid as well as both efficiently scavenged free radicals.
机译：目的：评估Corchorus depressus Linn市售叶子的自由基清除和脂质过氧化抑制活性。通过体外化学分析。方法：使用1-二苯基-2-吡啶并肼基（DPPH）自由基测定法研究了四种不同的溶剂萃取物甲醇-CDM，乙醇-CDE，乙酸乙酯-CDEA和己烷-CDH的清除自由基活性，结果表示为SC 50 值。使用β-胡萝卜素-亚油酸模型系统评估了三种不同浓度（0.1、0.5和1.0 mg / mL）的脂质过氧化抑制活性，并将结果表示为氧化率比（R OR ） ，抗氧化活性（A A ）和抗氧化活性系数（C AA ）。将L-抗坏血酸-AA，α-生育酚-TOC和BHT用作参考化合物。还使用Folin-Ciocalteau试剂测定了这些提取物的总多酚含量。结果：提取物的总多酚含量以CDM> CDE> CDEA CDH的顺序降低。在DPPH自由基检测中，CDM的清除自由基活性（SC 50 ：216.27μg/ mL）高于CDE（327.84μg/ mL）和CDEA（544.28μg/ mL）。与天然抗氧化剂AA和TOC相比，总体排名按以下顺序降低：AA> CDM> TOC> CDE> CDEA CDH。在β-胡萝卜素-亚油酸模型系统中，CDM还具有比其他提取物更高的抗脂质过氧化保护活性，因为它的R OR （0.4903至0.2752）较低，A A （50.96至72.47）和C AA （280.58至513.13）。与BHT和TOC相比，CDM表现出比TOC更有希望的效力。在所研究的浓度0.5和1.0 mg / mL中，是最有效的抗亚油酸氧化的抗氧化剂。结论：无论采用何种方法，CDM均表现出最有利的抗氧化活性。 CDM和CDE对脂肪酸的氧化具有保护作用，并且可以有效清除自由基。

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