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首页> 外文期刊>European Journal of Medicinal Plants >Contraceptive and Phytochemical Profile of Lime- Yellow Pea (Macrotyloma axillare, E. Mey) Verdc: A Tropical Climber
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Contraceptive and Phytochemical Profile of Lime- Yellow Pea (Macrotyloma axillare, E. Mey) Verdc: A Tropical Climber

机译：石灰-黄豌豆（Macrotyloma axillare，E。Mey）Verdc的避孕和植物化学特征：热带攀援者

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Background: Rising human population has detrimental effects on quality of life and lead to increased cases of pollution and poverty. Modern forms of contraceptives also have severe side effects and result in high cases of unwanted pregnancies. As a result, several cases of illegal abortion, leading to serious health complications have been reported, and more than 30 million US dollars are used to treat post-abortion complications in Kenya annually. Herbal contraceptives offer alternatives to health problems, and this study was novel with significant findings, since little information exists about the pharmacological properties of M. axillare , unlike its closely related species, M. uniflorum , which has been extensively studied and established to have great pharmacological potential. Aims: To establish and validate the use of M. axillare extracts as traditional contraceptives and also to profile the phytochemicals responsible for its contraceptive activity. Place and Duration of Study: Department of Veterinary Anatomy and Physiology, University of Nairobi, Kenya. Methodology: The contraceptive effects were investigated by in vivo studies using Virgin Wistar female rats ( Rattus norvegicus ) with regular oestrus cycle. Qualitative and quantitative phytochemical profiling was carried out using standard procedures while GC-MS analysis was employed in the identification of compounds present in the methanolic extracts. Results: Macroscopic and microscopic examination of female reproductive tract revealed reduced ovary size, involuted uterus and persistent corpus luteum in the ovary and no births were recorded in groups treated with higher doses of the plant extracts. The presence of saponins, alkaloids, steroids and terpenoids, as well as phenolic compounds like tannins and flavonoids, which could be responsible for the contraceptive activity observed, either acting independently or synergistically, was confirmed through qualitative phytochemical analysis. GC-MS profile also led to the identification of compounds that included sitosterol, stigmasterol, stigmasta-3,5-dien-7-one, stigmastan-3,5-diene and campesterol that have structural similarities to known reproductive hormones and conventional contraceptives and could, therefore, be responsible for the observed contraceptive activity of the plant extract. Conclusion: The tested methanolic extracts have a potential contraceptive activity that warrants further investigations towards the development of novel plant-based contraceptives.
机译：背景：人口增长对生活质量产生不利影响，并导致污染和贫困案件增加。现代形式的避孕药具也有严重的副作用，并导致大量意外怀孕。结果，据报导有几起非法堕胎病例，导致严重的健康并发症，肯尼亚每年用于堕胎后并发症的治疗费用超过3000万美元。草药避孕药可以替代健康问题，并且这项研究是新颖的，具有重要发现，因为关于其的药理学特性的信息很少，与紧密相关的物种曼弗洛姆菌不同，该药物已被广泛研究并确定具有很大的应用前景。药理潜力。目的：建立并验证腋臭支原体提取物作为传统避孕药具的用途，并概述引起其避孕活性的植物化学物质。研究的地点和持续时间：肯尼亚内罗毕大学兽医解剖与生理学系。方法：使用具有正常发情周期的维京维斯塔雌性大鼠（Rattus norvegicus）通过体内研究研究了避孕效果。使用标准程序进行定性和定量植物化学分析，而GC-MS分析用于鉴定甲醇提取物中存在的化合物。结果：雌性生殖道的肉眼和显微镜检查显示，卵巢尺寸减小，子宫内卷，子宫内膜和黄体持续存在，使用较高剂量的植物提取物治疗的组中无出生记录。通过定性植物化学分析证实了皂苷，生物碱，类固醇和类萜以及酚类化合物（如单宁和类黄酮）的存在，它们可能与所观察到的避孕活性无关或协同作用。 GC-MS分析还可以鉴定出与已知的生殖激素和常规避孕药具有结构相似性的化合物，包括谷固醇，豆甾醇，豆甾醇，stigmasta-3,5-dien-7-one，stigmastan-3,5-diene和campesterol因此，可能与观察到的植物提取物的避孕作用有关。结论：经测试的甲醇提取物具有潜在的避孕作用，值得对新型植物性避孕药的开发进行进一步研究。

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