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首页> 外文期刊>European Chemical Bulletin >IN VITRO SUSTAINED DELIVERY OF ATENOLOL, AN ANTIHYPERTENSIVE DRUG USING NATURALLY OCCURRING CLAY MINERAL MONTMORILLONITE AS A CARRIER
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IN VITRO SUSTAINED DELIVERY OF ATENOLOL, AN ANTIHYPERTENSIVE DRUG USING NATURALLY OCCURRING CLAY MINERAL MONTMORILLONITE AS A CARRIER

机译：体外持续释放的替硝洛尔，一种抗高血压药物，使用天然粘土矿物蒙脱土作为载体

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摘要

In the present study, a naturally occurring clay mineral, Montmorillonite, (Mt) has been explored as a carrier for an antihypertensive drug, Atenolol. The effect of pH, time and initial drug concentration on drug loading capacity of Mt has been evaluated. The adsorption isotherm was fitted by the Langmuir model and follows the pseudo-second-order kinetics. The synthesized Mt-Atenolol complexes were characterized by XRD, FTIR, TGA, DSC etc. XRD data indicates the intercalation of Atenolol within the Mt layers. The release profile of the Atenolol from Mt-Atenolol complexes is compared with the pure Atenolol, in simulated gastric and intestinal fluids. The release behaviour of Atenolol from MT-Atenolol Complexes appears to be in sustained manner over a period of 24 hours and reaches upto 40% and 27% in simulated gastric and intestinal fluids respectively. As compared to pure Atenolol, extended gastric retention time was observed for Atenolol-Mt complexes indicative of the increased extent of absorption and bioavailability of the drug. Various kinetic models were used to elucidate the drug release mechanism, the best fitting was found for Higuchi and Korsmeyer-Peppas model. The synthesized Atenolol-Mt complexes have the potential for developing in to a sustained release formulation for oral drug delivery. Thus, proposing a promising formulation for oral sustained drug delivery of Atenolol.
机译：在本研究中，已经研究了天然粘土矿物蒙脱土（Mt）作为抗高血压药物阿替洛尔的载体。评估了pH，时间和初始药物浓度对Mt载药量的影响。吸附等温线由Langmuir模型拟合，并遵循拟二级动力学。合成的Mt-阿替洛尔复合物通过XRD，FTIR，TGA，DSC等进行表征。XRD数据表明阿替洛尔在Mt层中的嵌入。在模拟的胃液和肠液中，比较了阿替洛尔从Mt-阿替洛尔复合物中的释放曲线与纯阿替洛尔的释放情况。阿替洛尔从MT-阿替洛尔复合物中的释放行为似乎持续24小时，在模拟的胃液和肠液中分别达到40％和27％。与纯阿替洛尔相比，阿替洛尔-Mt复合物的胃滞留时间延长，表明该药物的吸收程度和生物利用度增加。各种动力学模型被用来阐明药物释放机理，Higuchi和Korsmeyer-Peppas模型被发现是最佳拟合。合成的Atenolol-Mt复合物具有发展为口服药物递送的缓释制剂的潜力。因此，提出了一种有前途的口服阿替洛尔药物制剂。

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