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首页> 外文期刊>European Journal of Histochemistry >Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer
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Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer

机译：Nestin表达与局部晚期（T4）乳腺癌的不良预后和三阴性表型有关

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Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients’ outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers.
机译：Nestin是一种中间丝蛋白，传统上因其作为神经干细胞标志物的重要性而闻名。但是，近年来，巢蛋白的表达已表明与肿瘤内祖细胞群体的普遍增殖有关。目前尚无针对T4乳腺癌患者巢蛋白表达的研究报道。因此，本研究的目的是通过免疫组织化学研究巢蛋白在T4乳腺癌中的表达和分布，以确定其与临床和病理学参数以及患者预后的关系。巢蛋白在血液微血管的肿瘤细胞和内皮细胞中可检测到，并且在T4乳腺肿瘤的三阴性和炎性乳腺癌（IBC）亚组中明显表达。 Kaplan-Meier分析显示，在T4乳腺癌患者中，肿瘤细胞中Nestin的存在显着预测了5年生存期的不良预后（P = 0.02）和10年生存期的临界意义（P = 0.05）。基于这些观察，我们推测巢蛋白的表达可能是具有侵略性临床行为的肿瘤的特征，这表明巢蛋白在肿瘤细胞和血管中的存在可能被认为是导致不良预后的重要因素。等待进一步的研究来确定巢蛋白在这些乳腺癌亚组的病因中的生物学作用。

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