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首页> 外文期刊>European Journal of Histochemistry >Protein misfolding and cellular stress in disease and ageing - Concepts and protocols
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Protein misfolding and cellular stress in disease and ageing - Concepts and protocols

机译：疾病和衰老中的蛋白质错误折叠和细胞应激-概念和方案

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To those readers that already got the Protein misfolding and disease volume, this new title can sound as an update or a second edition of the previous volume: well, this is not the case. To those colleagues that would like to enter the fascinating field of protein’s misfolding this new volume constitutes an excellent opportunity to be driven on the causes and mechanisms that are actually know to produce the misfolding. For both types of scientists this volume is a must: the subtitle already sounds as a warning since it reads concepts and protocols rather than methods and protocols . In other words, there is an entire section (part I, chapters 1-8) devoted to explain the concepts and the approaches we have gathered in these last years on the misfolding. These chapters are presented in the review style so that the relevant bibliographies are all there; in addition, this section is presenting the conceptual paradigma linking protein misfolding to ageing by conceiving the disease itself as premature ageing processes. Thus, the reader can take profit from this first part and become acquiented on the molecular effects brought about by protein misfolding at a cellular level and, generally speaking, on the pathogenetic mechanisms thereafter triggered by soluble prefibrillar aggregates...
机译：对于那些已经了解了蛋白质错误折叠和疾病卷的读者，这个新标题听起来可能是前一卷的更新或第二版：嗯，事实并非如此。对于那些希望进入迷人的蛋白质错误折叠领域的同事来说，这个新的数量构成了一个极好的机会，可以推动人们真正了解导致错误折叠的原因和机制。对于这两种类型的科学家来说，这本书都是必须的：因为它读的是概念和协议，而不是方法和协议，所以副标题听起来已经是警告。换句话说，整个章节（第一部分，第1-8章）专门解释了这些年来我们在错误折叠方面收集的概念和方法。这些章节以复习样式呈现，因此相关的参考书目都在那里。此外，本节通过将疾病本身视为过早的衰老过程，提出了将蛋白质错误折叠与衰老联系起来的概念性悖论。因此，读者可以从第一部分中获利，并熟悉蛋白质在细胞水平上错误折叠所带来的分子效应，以及一般而言，其后由可溶性原纤维前体聚集物引发的致病机制。

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