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首页> 外文期刊>European review for medical and pharmacological sciences. >Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats
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Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats

机译：戊乙奎定联合依达拉奉治疗急性脑梗死及其对大鼠血清TNF-α和NDS评分的影响

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OBJECTIVE: To investigate the effects of penehyclidine combined with edaravone on acute cerebral infarction (ACI) in rats. MATERIALS AND METHODS: A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model and treatment group. After grouping, rats in the treatment groups were treated with edaravone combined with phenecyclidine. The rats in the sham and model group were given an equal volume of phosphate-buffered saline (PBS). The therapeutic effects on rats at 3 d and 7 d after treatment were observed, the levels of serum TNF-α, interleukin-6 (IL-6) and high-mobility group box 1 protein (HMGB1) before and after treatment were compared, and the NDS scores were recorded. RESULTS: After treatment, the effective rate in treatment groups was higher than that in control group. The expression levels of serum TNF-α, HMGB1 and IL-6 in treatment groups showed gradually decreasing trends after treatment, and there were significant differences in the levels before and after treatment (p<0.05). At 3 d, the decrease ranges of expression levels of TNF-α, HMGB1, and IL-6 in model and treatment groups were larger than those in control group; there were statistically significant differences in the expression levels between the two groups (p<0.05). The NDS score was gradually decreased after treatment, while the activities of daily living (ADL) score were gradually increased after treatment. There were significant differences in the scores between the two groups at each time point (p<0.05). There were positive correlations of the expression levels of serum IL-6 and HMGB1 with the expression level of TNF-α (correlation coefficient=0.8731 and 0.9084, p<0.01), and there was also a positive correlation between the TNF-α level and the NDS score (correlation coefficient=0.8331, p<0.01). CONCLUSIONS: Penehyclidine combined with edaravone has a better clinical treatment effect on ACI rats, which can significantly reduce the levels of serum TNF-α, IL-6 and HMGB1 and the NDS score, so it is worthy of popularization in clinical application.
机译：目的：研究戊乙奎定联合依达拉奉对大鼠急性脑梗死的影响。材料与方法：建立大鼠大脑中动脉梗死模型。将大鼠随机分为假手术组，模型组和治疗组。分组后，将治疗组的大鼠用依达拉奉联合苯环利定治疗。假手术和模型组的大鼠被给予等体积的磷酸盐缓冲盐水（PBS）。观察治疗后3 d和7 d对大鼠的治疗作用，比较治疗前后血清TNF-α，白细胞介素6（IL-6）和高迁移率族box 1蛋白（HMGB1）的水平，并记录NDS分数。结果：治疗后，治疗组的有效率高于对照组。治疗后血清TNF-α，HMGB1和IL-6的表达水平呈逐渐下降趋势，治疗前后差异有统计学意义（p <0.05）。 3 d时，模型组和治疗组TNF-α，HMGB1和IL-6表达水平的下降幅度大于对照组。两组之间的表达水平差异有统计学意义（p <0.05）。治疗后NDS评分逐渐降低，而治疗后日常生活活动（ADL）评分逐渐升高。两组在每个时间点的得分都有显着差异（p <0.05）。血清IL-6和HMGB1的表达水平与TNF-α的表达呈正相关（相关系数分别为0.8731和0.9084，p <0.01），TNF-α的表达与TNF-α的表达呈正相关。 NDS评分（相关系数= 0.8331，p <0.01）。结论：戊乙奎啶联合依达拉奉对ACI大鼠有较好的临床治疗效果，能显着降低血清TNF-α，IL-6和HMGB1水平及NDS评分，值得在临床上推广应用。

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