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首页> 外文期刊>European Journal of Preventive Medicine >Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients
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Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients

机译：优化ω-3脂肪酸对代谢综合征患者血脂谱的影响

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Background: The metabolic syndrome is a clustering of metabolic abnormalities and cardiovascular risk factors. It is vital to start the lifestyle interventions and treatment early in patients with metabolic syndrome to prevent the twin global epidemics of type 2diabetes and CVD. Objective: to investigate the overall effects of omega-3 fatty acids supplementation In addition to Dietary Approaches to Stop Hypertension (DASH) nutritional intervention on the lipid profile in patients with metabolic syndrome and to study if the addition of DASH diet will alleviate the rise in LDL- C that occurs with ω-3 fatty acid supplementation. Research design and methods: This was a prospective interventional outpatient trial conducted on 42 patients with the metabolic syndrome. They received ω-3 fatty acid supplementation 1 g/d in addition to DASH nutritional education for 12 weeks: the DASH diet with increased consumption of fruit, vegetables, low-fat dairy and whole grains and lower in saturated fat, total fat, and cholesterol. The main outcome measures were the lipid profile of the patients with metabolic syndrome. Results: ω-3 fatty acid together with The DASH diet significantly changed the mean of all parameters of lipid profile in metabolic syndrome patients. After 12 weeks, there was a significant increase in HDL-C (14%), significant reductions in TG (37.7%), LDL (29.4%) and a significant reduction in Non HDL-C (24.7%). Conclusion: this study demonstrated that the DASH diet optimizes and complements the effect of ω-3 fatty acid on the lipid profile of patients with metabolic syndrome by alleviating the rise in LDL- C that occurs with omega supplementation.
机译：背景：代谢综合征是代谢异常和心血管危险因素的聚集。对代谢综合征患者尽早开始生活方式干预和治疗，对于预防2型糖尿病和CVD的双重全球性流行病至关重要。目的：研究补充ω-3脂肪酸的补充饮食，以及通过饮食途径停止高血压（DASH）营养干预对代谢综合征患者的脂质谱的影响，并研究添加DASH饮食是否可以缓解肥胖的增加。补充ω-3脂肪酸时发生的LDL-C。研究设计和方法：这是一项针对42位代谢综合征患者的前瞻性干预性门诊试验。除了接受DASH的营养教育外，他们还接受了1 g / d的ω-3脂肪酸补充，为期12周：DASH饮食中水果，蔬菜，低脂乳制品和全谷物的消耗量增加，饱和脂肪，总脂肪和胆固醇。主要结果指标是代谢综合征患者的脂质分布。结果：ω-3脂肪酸与DASH饮食一起显着改变了代谢综合征患者血脂谱所有参数的平均值。 12周后，HDL-C显着增加（14％），TG（37.7％），LDL（29.4％）显着降低，而非HDL-C（24.7％）显着降低。结论：这项研究表明，DASH饮食可以减轻ω-3脂肪酸对代谢综合症患者脂质谱的影响，从而减轻和补充ω-脂肪酸的摄入，从而增加并补充ω-3脂肪酸对脂代谢的影响。

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