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首页> 外文期刊>Experimental Animals >Lack of B Cell Leakiness in BALB/cA- nu , scid Double Mutant Mice
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Lack of B Cell Leakiness in BALB/cA- nu , scid Double Mutant Mice

机译：BALB / cA-nu，scid双突变小鼠中缺乏B细胞渗漏

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BALB/cA mice homozygous for both nu and scid mutations (BALB/cA-nuu, scid/scid) were developed by mating between BALB/cA-scid and BALB/cA-nu. These mice have greater longevity than C.B-17-scid because no thymic lymphoma occurs in them unlike in the latter. C.B-17-scid is known to show the leaky phenomenon in which a few clones of functional T and B cells develop in aged C.B-17-scid. Unexpectedly, the leaky B cells and T cells were absent or suppressed in BALB/cA-nu, scid mice when cytokine expressions were determined by RT-PCR, lymphocyte phenotypes by flow cytometry and serum immunoglobulin levels by ELISA. These results indicate that B cell leakiness may be induced by leaked T cells. BALB/cA-nu, scid mice may be useful as a recipient in allo- and xeno-transplantation experiments because of the absence of both thymic lymphomas and leakiness, in addition to lack of hair.
机译：通过在BALB / cA-scid和BALB / cA-nu之间交配，发育出对于nu和scid突变（BALB / cA-nu / nu，scid / scid）纯合的BALB / cA小鼠。这些小鼠的寿命比C.B-17更长，因为它们没有胸腺淋巴瘤的发生，与后者不同。已知C.B-17 scid显示出漏液现象，其中一些功能性T和B细胞克隆在老化的C.B-17 scid中发育。出乎意料的是，当通过RT-PCR测定细胞因子表达，通过流式细胞术测定淋巴细胞表型和通过ELISA测定血清免疫球蛋白水平时，BALB / cA-nu，scid小鼠中缺少或抑制了渗漏的B细胞和T细胞。这些结果表明，泄漏的T细胞可能引起B细胞泄漏。 BALB / cA-nu，scid小鼠可以用作同种异体和异种移植实验的受体，因为除了缺乏毛发外，还没有胸腺淋巴瘤和渗漏。

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