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首页> 外文期刊>Experimental Animals >Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration
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Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration

机译：伊伐布雷定对无症状二尖瓣变性犬的心率和心肌耗氧量的急性影响

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Degenerative mitral valve disease (DMVD) is a common cardiac disease in geriatric dogs characterized by the degeneration of the mitral valve, leading to decreased cardiac output and activation of the sympathetic and renin-angiotensin-aldosterone system. This disease results in an increased resting heart rate (HR) and myocardial oxygen consumption (MVO2). A recent publication demonstrated that dogs with asymptomatic DMVD had a significantly higher HR and systemic blood pressure (BP) than age-matched control dogs. This higher HR will eventually contribute to increased MVO2. This study aimed to determine the effects of a single oral dose of ivabradine on the HR, MVO2 as assessed by the rate-pressure product, and BP in dogs with asymptomatic DMVD. Seven beagles with naturally occurring DMVD were instrumented by the Holter recorder and an oscillometric device to measure electrocardiogram and BP for 24 and 12 h, respectively. Each dog was randomly subjected to receive either placebo or ivabradine (0.5, 1.0 and 2.0 mg/kg). The results revealed that oral administration of ivabradine significantly decreased the HR and rate-pressure product in a dose-dependent manner without adverse effects. The highest dose of 2.0 mg/kg significantly reduced systolic and mean BP. Therefore, the findings imply that a single oral ivabradine administration at a dose of 1.0 mg/kg is suitable for dogs with asymptomatic DMVD to reduce the HR and MVO2 without marked effects on BP. This may potentially make ivabradine promising for management of an elevated HR in DMVD dogs.
机译：退行性二尖瓣疾病（DMVD）是老年犬常见的心脏病，其特征是二尖瓣退化，导致心输出量下降以及交感神经和肾素-血管紧张素-醛固酮系统的激活。该疾病导致静息心率（HR）和心肌耗氧量（MVO2）增加。最近的出版物表明，无症状DMVD的狗比年龄匹配的对照狗具有更高的HR和全身血压（BP）。较高的人力资源最终将有助于增加MVO2。这项研究旨在确定单剂量口服伊伐布雷定对无症状DMVD犬的HR，MVO2的影响（通过速率压力乘积和BP评估）。用Holter记录仪和示波仪器对七只具有自然DMVD的小猎犬进行测量，分别测量24小时和12小时的心电图和血压。每只狗随机接受安慰剂或伊伐布雷定（0.5、1.0和2.0 mg / kg）。结果表明，口服伊伐布雷定以剂量依赖的方式显着降低了心率和心率压积，而无不良影响。 2.0 mg / kg的最高剂量可显着降低收缩压和平均BP。因此，该发现暗示以1.0mg / kg的剂量单次口服伊伐布雷定施用适合于无症状DMVD的狗以降低HR和MVO 2，而对BP没有明显影响。这可能使伊伐布雷定有望在DMVD狗中用于治疗升高的HR。

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