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首页> 外文期刊>Experimental Hematology Oncology >BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation
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BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation

机译：BIRC6（APOLLON）在急性髓细胞白血病中被下调，其敲低会减弱中性粒细胞的分化

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Background Inhibitors of apoptosis (IAPs) were intensively investigated in the context of cancer where they promote tumor growth and chemoresistence. Overexpression of the IAP BIRC6 is associated with unfavorable clinical features and negatively impacts relapse-free survival in childhood acute myeloid leukemia (AML). Currently, BIRC6 levels in adult primary AML have not been compared to the expression in normal myeloid cells. Thus, we compared for the first time BIRC6 levels in adult primary AML patient samples to normal myeloid cells and studied its regulation and function during neutrophil differentiation. Findings We found significantly lower BIRC6 levels in particular AML subtypes as compared to granulocytes from healthy donors. The lowest BIRC6 expression was found in CD34+ progenitor cells. Moreover, BIRC6 expression significantly increased during neutrophil differentiation of AML cell lines and knocking down BIRC6 in NB4 acute promyelocytic leukemia (APL) cells significantly impaired neutrophil differentiation, but not cell viability. Conclusion Together, we found an association of low BIRC6 levels with an immature myeloid phenotype and describe a function for BIRC6 in neutrophil differentiation of APL cells.
机译：背景技术在癌症的背景下，对凋亡抑制因子（IAPs）进行了深入研究，它们促进了肿瘤的生长和化学持久性。 IAP BIRC6的过表达与不良的临床特征有关，并且对儿童急性髓性白血病（AML）的无复发生存产生负面影响。目前，尚未将成人原发性AML中的BIRC6水平与正常骨髓细胞中的表达进行比较。因此，我们首次将成人原发性AML患者样本中的BIRC6水平与正常髓样细胞进行了比较，并研究了其在嗜中性粒细胞分化过程中的调节和功能。结果我们发现，与来自健康供体的粒细胞相比，特别是AML亚型的BIRC6水平明显降低。在CD34 + 祖细胞中发现最低的BIRC6表达。此外，在AML细胞系嗜中性粒细胞分化过程中，BIRC6表达显着增加，而敲除NB4急性早幼粒细胞白血病（APL）细胞中的BIRC6则显着损害嗜中性粒细胞分化，但不损害细胞活力。结论在一起，我们发现低BIRC6水平与未成熟的骨髓表型相关，并描述了BIRC6在APL细胞嗜中性粒细胞分化中的功能。

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