...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Hematology Oncology >Ratio of involved/uninvolved immunoglobulin quantification by Hevylite? assay: clinical and prognostic impact in multiple myeloma
【24h】

Ratio of involved/uninvolved immunoglobulin quantification by Hevylite? assay: clinical and prognostic impact in multiple myeloma

机译：Hevylite定量参与/未参与免疫球蛋白的比例？分析：多发性骨髓瘤的临床和预后影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background HevyLite? is a new, recently developed method that facilitates separate quantification of the kappa- and lambda-bounded amounts of a given immunoglobulin (Ig). Using this method, we measured intact immunoglobulin (heavy/light chain; HLC) IgG -kappa, IgG -lambda, IgA -kappa, IgA -lambda individually, as well as their deriving ratios (HLCR) in a series of IgG or IgA multiple myeloma (MM) patients, to investigate and assess the contribution of these tests to disease evaluation. Patients and methods HevyLite? assays were used in sera from 130 healthy individuals (HI) and 103 MM patients, at time of diagnosis. In patients, the level of paraprotein was IgG in 78 (52 IgG -kappa, 26 IgG -lambda) and IgΑ in 25 (13 IgΑ-kappa, 12 IgΑ-lambda). Durie-Salmon and International Staging System stages were evenly distributed. Symptomatic patients (n = 77) received treatment while asymptomatic ones (n = 26) were followed. Patients' median follow-up was at 32.6 months. HLCR was calculated with the involved Ig (either G or A) as numerator. Results In HI, median IgG -kappa was 6.85, IgG -lambda 3.81, IgA -kappa 1.19 and IgA -lambda 0.98 g/L. The corresponding median involving HLC values in MM patients were 25.8, 23.45, 28.9 and 36.4 g/L. HLC- IgG related to anemia, high serum free light chain ratio and extensive bone marrow infiltration, while high HLCR correlated with the same plus increased β2-microglobulin. In addition, increased HLCR and the presence of immunoparesis correlated with time to treatment. Patients with high HLCR had a significantly shorter survival ( p = 0.022); HLCR retained its prognostic value in multivariate analysis. Conclusions HLC and HLCR quantify the precise amount of the involved immunoglobulin more accurately than other methods; moreover, they carry prognostic information regarding survival in MM patients.
机译：背景HevyLite？是一种新近开发的方法，可促进对给定免疫球蛋白（Ig）的κ和λ结合量进行单独定量。使用这种方法，我们分别测量了完整的免疫球蛋白（重链/轻链; HLC）IgG-κ，IgG -lambda，IgA-κ，IgA -lambda，以及它们在一系列IgG或IgA中的衍生比（HLCR）骨髓瘤（MM）患者，以调查和评估这些检查对疾病评估的贡献。患者和方法HevyLite？在诊断时，对130名健康个体（HI）和103 MM患者的血清进行了检测。在患者中，副蛋白的水平为78（52 IgG-κ，26 IgG-λ）中的IgG和25（13IgA-κ，12IgA-λ）中的IgA。 Durie-Salmon和International Staging System阶段分布均匀。有症状的患者（n = 77）接受治疗，而无症状的患者（n = 26）接受治疗。患者的中位随访时间为32.6个月。 HLCR是用涉及的Ig（G或A）作为分子来计算的。结果在HI中，IgG-κ中位数为6.85，IgG-λ3.81，IgA-κ1.19和IgA-λ0.98 g / L。 MM患者相应的涉及HLC值的中位数为25.8、23.45、28.9和36.4 g / L。 HLC-IgG与贫血，高血清游离轻链比率和广泛的骨髓浸润有关，而高HLCR与相同的β2-微球蛋白增加有关。此外，HLCR升高和免疫性贫血的存在与治疗时间相关。高HLCR患者的生存期明显缩短（p = 0.022）; HLCR在多变量分析中保留了其预后价值。结论HLC和HLCR比其他方法更准确地定量了所涉及免疫球蛋白的精确量。此外，它们携带有关MM患者生存的预后信息。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号