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首页> 外文期刊>Eukaryotic cell >Stress-Specific Role of Fission Yeast Gcn5 Histone Acetyltransferase in Programming a Subset of Stress Response Genes
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Stress-Specific Role of Fission Yeast Gcn5 Histone Acetyltransferase in Programming a Subset of Stress Response Genes

机译：裂变酵母Gcn5组蛋白乙酰转移酶在编程应激反应基因亚组中的应激特异性作用

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Gcn5 is a coactivator protein that contributes to gene activation by acetylating specific lysine residues within the N termini of histone proteins. Gcn5 has been intensively studied in the budding yeast, Saccharomyces cerevisiae, but the features of genes that determine whether they require Gcn5 during activation have not been conclusively clarified. To allow comparison with S. cerevisiae, we have studied the genome-wide role of Gcn5 in the distantly related fission yeast, Schizosaccharomyces pombe. We show that Gcn5 is specifically required for adaptation to KCl- and CaCl2-mediated stress in S. pombe. We have characterized the genome-wide gene expression responses to KCl stress and show that Gcn5 is involved in the regulation of a subset of stress response genes. Gcn5 is most clearly associated with KCl-induced genes, but there is no correlation between Gcn5 dependence and the extent of their induction. Instead, Gcn5-dependent KCl-induced genes are specifically enriched in four different DNA motifs. The Gcn5-dependent KCl-induced genes are also associated with biological process gene ontology terms such as carbohydrate metabolism, glycolysis, and nicotinamide metabolism that together constitute a subset of the ontology parameters associated with KCl-induced genes.
机译：Gcn5是一种辅助激活蛋白，通过乙酰化组蛋白N末端的特定赖氨酸残基来促进基因激活。 Gcn5已在萌芽的酿酒酵母中进行了深入研究，但尚未明确阐明在激活过程中是否需要Gcn5的基因特征。允许与 S进行比较。酿酒酵母，我们研究了Gcn5在远缘裂殖酵母裂殖酵母（Schizosaccharomyces pombe）中的全基因组作用。我们表明，Gcn5是专门适应Kem-和CaCl 2 介导的 S胁迫的。蓬贝。我们已经表征了对KCl胁迫的全基因组基因表达反应，并表明Gcn5参与了应激反应基因子集的调控。 Gcn5与KCl诱导的基因最明显相关，但Gcn5依赖性与其诱导程度之间没有相关性。取而代之的是，依赖于Gcn5的KCl诱导的基因在四个不同的DNA基序中被特异地富集。 Gcn5依赖性KCl诱导的基因还与生物学过程基因本体术语相关联，例如碳水化合物代谢，糖酵解和烟酰胺代谢，它们共同构成了与KCl诱导基因相关的本体参数的子集。

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