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Pathophysiological Analysis of Female Spontaneously Diabetic Torii Fatty Rats

机译：雌性糖尿病性鸟居肥胖大鼠的病理生理分析

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Obesity, hyperglycemia, hyperlipidemia, and diabetes-associated complications appear at younger ages (6-8 weeks) in the male Spontaneously Diabetic Torii- Leprfa (SDT- fa/fa ) rat than in the male original SDT (SDT-+/+) rat. However, the incidence and progression of diabetes mellitus and diabetic complications in the female SDT- fa/fa rat have not been reported in detail. In the present study, the pathophysiological features of the female SDT- fa/fa rat were examined, and compared with those of the female SDT-+/+ rat. Female SDT- fa/fa rats showed hyperphagia, obesity, hyperglycemia, and hyperlipidemia from 5 or 6 weeks of age, and hyperinsulinemia was observed from 5 to 12 weeks. Pathological changes pancreatic islets were observed from 8 weeks. Renal function parameters, such as urine volume and urinary protein, increased from 16 weeks, and pathological findings in the renal tubule, and cataracts were also observed from 16 weeks. Increases of visceral and subcutaneous fats were obvious during the observation period. In pair-feeding with SDT-+/+ rats, SDT- fa/fa rats showed improved hyperglycemia and hypertriglycemia, but hypercholesterolemia was not entirely improved during the study period. Female SDT- fa/fa rats showed diabetes mellitus and diabetes-associated complications at young ages, and fat accumulation was remarkable. Suppression of hyperphagia in SDT- fa/fa rats was effective at improving hyperglycemia and hypertriglycemia. In conclusion, the female SDT- fa/fa rat has the potential to become an important animal model of type 2 diabetes mellitus with obesity, especially for women, for which few models currently exist.
机译：雄性自发性糖尿病Torii-Lepr fa （SDT-fa / fa）大鼠的肥胖，高血糖，高血脂和糖尿病相关并发症出现在较年轻的年龄（6-8周）。 SDT（SDT-+ / +）大鼠。但是，尚未详细报道雌性SDT-fa / fa大鼠中糖尿病的发生和发展以及糖尿病并发症。在本研究中，检查了雌性SDT-fa / fa大鼠的病理生理特征，并将其与雌性SDT-+ / +大鼠的病理生理特征进行了比较。雌性SDT-fa / fa大鼠从5或6周龄开始出现食欲亢进，肥胖，高血糖和高血脂，在5至12周出现高胰岛素血症。从8周开始观察到胰岛的病理变化。从16周开始，肾功能参数（如尿量和尿蛋白）增加，从16周开始还观察到肾小管和白内障的病理结果。在观察期间内脏和皮下脂肪的增加是明显的。在与SDT-+ / +大鼠配对喂养中，SDT-fa / fa大鼠表现出高血糖和高三血糖改善，但在研究期间高胆固醇血症并未完全改善。雌性SDT-fa / fa大鼠在年轻时就表现出糖尿病和与糖尿病相关的并发症，并且脂肪堆积显着。 SDT-fa / fa大鼠食欲亢进的抑制可有效改善高血糖症和高血糖症。总之，雌性SDT-fa / fa大鼠有可能成为肥胖的2型糖尿病的重要动物模型，特别是对于女性而言，目前尚无这种模型。

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