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首页> 外文期刊>Experimental Animals >Effect of Resveratrol on Behavioral Performanceof Streptozotocin-induced Diabetic Mice inAnxiety Tests
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Effect of Resveratrol on Behavioral Performanceof Streptozotocin-induced Diabetic Mice inAnxiety Tests

机译：白藜芦醇对链脲佐菌素诱导的糖尿病小鼠行为学行为的焦虑测试

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摘要

The aim of this study was to evaluate with anxiety tests the effect of resveratrol (RSV) on streptozotocin (STZ)-induced diabetic mouse behavioral performance at the second and fourth week of treatment. Confirmed diabetic mice (>250 mg/dl of glucose in blood after STZ injection) were treated with RSV (RDM, n=12) or control treated (DM, n=12) for 4 weeks. DM and RDM were tested in the Open Field Test (OFT) and Elevated Plus Maze (EPM). In the second week of RSV treatment, a higher grooming frequency ( P <0.05) and a lower defecation and rearing frequency ( P <0.05) were detected in the OFT in the RDM group compared with the DM. There was a higher grooming frequency ( P <0.05) and higher percentage of entries in open arms ( P <0.05) in the RDM group than in the DM group in the EPM. However, in the fourth week of RSV treatment, the only effect observed was a higher grooming frequency in the RDM group than in the DM group ( P <0.05) in the EPM. In conclusion, RSV treatment in diabetic mice provoked anxiolytic-like effects in both tests (OFT and EPM), and these effects were observed in a short time window (2 weeks). It is suggested that RSV may help diabetic animals to adapt to new stressing and anxiety situations and thus to improve their welfare.
机译：这项研究的目的是通过焦虑测试评估白藜芦醇（RSV）在治疗的第二和第四周对链脲佐菌素（STZ）诱导的糖尿病小鼠行为表现的影响。用RSV（RDM，n = 12）或对照组（DM，n = 12）治疗确诊的糖尿病小鼠（STZ注射后血液中葡萄糖> 250 mg / dl）4周。 DM和RDM在野外测试（OFT）和高架迷宫（EPM）中进行了测试。在RSV治疗的第二周，与DM相比，RDM组的OFT检测到较高的修饰频率（P <0.05）和较低的排便和饲养频率（P <0.05）。与EPM中的DM组相比，RDM组的梳理频率更高（P <0.05），并且张开双臂的进入百分比更高（P <0.05）。然而，在RSV治疗的第4周，在EPM中，观察到的唯一效果是RDM组的梳理频率高于DM组（P <0.05）。总之，在两种测试中（OFT和EPM），糖尿病小鼠的RSV治疗均引起了抗焦虑药样作用，并且在短时间内（2周）观察到了这些作用。建议RSV可以帮助糖尿病动物适应新的压力和焦虑状况，从而改善其福利。

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