The importance of PTHrP for cancer development

Dr. Jürgen Dittmer

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The importance of PTHrP for cancer development

机译：PTHrP对癌症发展的重要性

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Parathyroid hormone-related protein (PTHrP) is expressed by many cells and usually acts as an autocrine, paracrine and/or intracrine factor to play numerous roles in embryonic development and normal physiology. Evidence has been accumulated suggesting that PTHrP may also serve important functions in tumor development. PTHrP has the potential to cause humoral hypercalcaemia of malignancy and is able to induce local osteolysis which facilitates growth of tumor cells that have metastasized to bone. Furthermore, PTHrP has been shown to stimulate proliferation as well as invasiveness of cancer cells and to protect cancer cells from apoptosis. In this review, I summarize the current knowledge about the role of PTHrP in cancer development and about the factors that control PTHrP expression in cancer.

机译：甲状旁腺激素相关蛋白（PTHrP）在许多细胞中表达，通常充当自分泌，旁分泌和/或内分泌因子，在胚胎发育和正常生理中起多种作用。已有证据表明PTHrP可能还在肿瘤发展中起重要作用。 PTHrP有可能引起恶性体液性高钙血症，并能够诱导局部骨溶解，从而促进已转移至骨骼的肿瘤细胞的生长。此外，已显示PTHrP刺激癌细胞的增殖以及侵袭性并保护癌细胞免于凋亡。在这篇综述中，我总结了有关PTHrP在癌症发展中的作用以及控制PTHrP在癌症中表达的因素的最新知识。

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《Gene Therapy and Molecular Biology》 |2004年第2期|共14页
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Dr. Jürgen Dittmer;
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中图分类基础医学;
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1. Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation. [J] . Watson PH, Westhusin ME, Watson AJ Anatomy and embryology . 2001,第3期

机译：PTHrP处理后，卵母细胞成熟过程中，PTHrP和PTHR（PTH / PTHrP-r）mRNA和多肽在牛卵巢中的表达以及对牛胚泡发育的刺激。
2. PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. [J] . Schipani E, Provot S Birth defects research, Part C. Embryo today: reviews . 2003,第4期

机译：软骨内骨发育中的PTHrP，PTH和PTH / PTHrP受体。
3. Expression patterns of parathyroid hormone-related peptide (PTHrP) and parathyroid hormone receptor type 1 (PTHR1) during human development are suggestive of roles specific for each gene that are not mediated through the PTHrP/PTHR1 paracrine signali [J] . Sarah Cormier, Anne-Lise Delezoide, Caroline Silve Gene Expression Patterns: A Section of Mechanisms of Development . 2003,第1期

机译：在人类发育过程中，甲状旁腺激素相关肽（PTHrP）和甲状旁腺激素受体1型（PTHR1）的表达模式暗示了每种基因的特异性作用，这些作用不是通过PTHrP / PTHR1旁分泌信号介导的。
4. High Purity Synthesis of PTHrP (1-34) with Infrared Heating on the Tribute~R-UV-IR Peptide Synthesizer [C] . James P. Cain, Christina A. Chantell, Michael A. Onaiyekan American Peptide Symposium . 2013

机译：高纯度合成PTHRP（1-34），对致力〜R-UV-IR肽合成器的红外线加热
5. Studies of the effect of transforming growth factor-beta on PTHrP expression,mRNA stability, and secretion in epithelial cancers. [D] . Sellers, Rani Suzanne. 2001

机译：转化生长因子-β对上皮癌中PTHrP表达，mRNA稳定性和分泌的影响的研究。
6. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development [O] . Beate Lanske, Michael Amling, Lynn Neff, 1999

机译：PTHrP基因或PTH / PTHrP受体基因的切除导致骨骼发育异常
7. Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation. [O] . Watson, P H, Westhusin, M E, Watson, A J 2001

机译：在卵母细胞成熟过程中进行PTHrP处理后，PTHrP和PTHR（PTH / PTHrP-r）mRNA和多肽在牛卵巢中的表达以及对牛胚泡发育的刺激。
8. Parathyroid Hormone-Related Peptide (PTHrP) as a New Target for Metastatic Breast Cancer: Evaluation in Preclinical Models. [R] . Kremer, R., Camirand, A. 2016

机译：甲状旁腺激素相关肽（pTHrp）作为转移性乳腺癌的新靶点：临床前模型评估。

The importance of PTHrP for cancer development

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