A novel IL-6/IL-12 family cytokine IL-27 and itsantitumor activity

Dr. Takayuki Yoshimoto

首页> 外文期刊>Gene Therapy and Molecular Biology >A novel IL-6/IL-12 family cytokine IL-27 and itsantitumor activity

【24h】

A novel IL-6/IL-12 family cytokine IL-27 and itsantitumor activity

机译：新型IL-6 / IL-12家族细胞因子IL-27及其抗肿瘤活性

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Interleukin (IL)-12 is a heterodimeric pro-inflammatory cytokine, which plays a critical role in a link between innate and adaptive immunities and in the development of type 1 cell-mediated immunity. Novel heterodimeric cytokines IL-23 and IL-27 with structural and functional similarities to IL-12 have been identified. These novel cytokines establish the IL-6/IL-12 family, whereas they mediate distinct cellular functions and roles, resulting in the coordinate regulation of Th1 development and type 1 cell-mediated immunity. Recent studies have revealed that both IL-23 and IL-27 possess a potent antitumor activity. Although IL-12 has a powerful antitumor activity against various tumors, IL-12 therapy has been limited by its systemic toxicities. Therefore, IL-23 and IL-27 may be alternative attractive candidates as therapeutic agents against tumors. This review summarizes recent advance on the roles of IL-27 in immune regulation and its antitumor activity.

机译：白介素（IL）-12是一种异源二聚体促炎细胞因子，在先天免疫和适应性免疫之间的联系以及1型细胞介导的免疫的发展中起着关键作用。已经鉴定出与IL-12具有结构和功能相似性的新型异二聚细胞因子IL-23和IL-27。这些新颖的细胞因子建立了IL-6 / IL-12家族，但它们介导不同的细胞功能和作用，从而导致Th1发育和1型细胞介导的免疫的协调调节。最近的研究表明，IL-23和IL-27均具有有效的抗肿瘤活性。尽管IL-12具有针对各种肿瘤的强大抗肿瘤活性，但IL-12治疗受到其全身毒性的限制。因此，IL-23和IL-27可以是替代的有吸引力的候选物作为抗肿瘤的治疗剂。这篇综述总结了IL-27在免疫调节中的作用及其抗肿瘤活性的最新进展。

著录项

来源
《Gene Therapy and Molecular Biology》 |2005年第2期|共8页
作者
Dr. Takayuki Yoshimoto;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类基础医学;
关键词

相似文献

外文文献
中文文献
专利

1. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27 [J] . Mingli Xu, Izuru Mizoguchi, Noriko Morishima, Clinical & developmental immunology. . 2010,第1期

机译：IL-12家族细胞因子，IL-12，IL-23和IL-27对抗肿瘤免疫反应的调节
2. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27 [J] . MingliXu, IzuruMizoguchi, NorikoMorishima, Developmental Immunology: Journal of Immunology Research . 2010,第2期

机译：IL-12家族细胞因子，IL-12，IL-23和IL-27对抗肿瘤免疫反应的调节
3. Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses. [J] . Hu S, Wong CK, Lam CW Immunobiology: Zeitschrift fur Immunitatsforschung . 2011,第1a2期

机译：IL-12家族细胞因子IL-27激活嗜酸性粒细胞：IL-27在变应性反应中的多效性作用的含义。
4. Cytokines of the IL-6 family in the modulation of carbohydrate and lipid metabolism in patients with metabolic syndrome [C] . Daria Skuratovskaia, Alexandra Komar, Maria Vulf, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：IL-6家族的细胞因子对代谢综合征患者糖脂代谢的调控
5. Role of immunoregulatory cytokines IL-12 and IL-23 in skin cancer. [D] . Nasti, Tahseen Hamid. 2014

机译：免疫调节细胞因子IL-12和IL-23在皮肤癌中的作用。
6. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines IL-12 IL-23 and IL-27 [O] . Mingli Xu, Izuru Mizoguchi, Noriko Morishima, 2010

机译：IL-12家族细胞因子IL-12IL-23和IL-27对抗肿瘤免疫反应的调节
7. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27 [O] . Xu, Mingli, Mizoguchi, Izuru, Morishima, Noriko, 2010

机译：IL-12家族细胞因子，IL-12，IL-23和IL-27对抗肿瘤免疫反应的调节

A novel IL-6/IL-12 family cytokine IL-27 and itsantitumor activity

摘要

著录项

相似文献

相关主题

期刊订阅