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首页> 外文期刊>Experimental and clinical transplantation >Immune Monitoring With a Lymphocyte Adenosine Triphosphate Assay in Kidney Transplant Recipients Treated With a Calcineurin Inhibitor
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Immune Monitoring With a Lymphocyte Adenosine Triphosphate Assay in Kidney Transplant Recipients Treated With a Calcineurin Inhibitor

机译：用钙调神经磷酸酶抑制剂治疗的肾脏移植受者中的淋巴细胞磷酸三磷酸腺苷含量的免疫监测

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Objectives: The adenosine triphosphate assay using peripheral lymphocytes may be useful to evaluate the risks of acute rejection and infection in kidney transplant patients. We used the adenosine triphosphate assay to evaluate differences between recipients who were treated with cyclosporine- or tacrolimus-based immunosuppressive therapy. Materials and Methods: Adenosine triphosphate levels were measured in peripheral CD4+ cells before and after transplant and were correlated with clinical outcomes in 45 kidney transplant recipients. These recipients received immunosuppressive therapy with either cyclosporine (23 patients) or tacrolimus (22 patients). Results: Adenosine triphosphate levels were significantly lower in the cyclosporine- than tacrolimus-based therapy groups from 2 to 6 weeks after transplant. Adenosine triphosphate levels were similar between these groups before and 1 week after transplant. The frequency of cytomegalovirus infection was greater in the recipients who received cyclosporine (17 patients [74%]) than tacrolimus (6 patients [27%]; P ≤ .003). The frequency of acute rejection episodes was similar between the cyclosporine and tacrolimus groups. Conclusions: These observations suggest that cyclosporine-based immunosuppressive therapy causes excessive immunosuppression compared with tacrolimus-based therapy, evidenced by the lymphocyte adenosine triphosphate levels. The adenosine triphosphate assay using peripheral CD4+ cells may be a useful method for predicting the occurrence of cytomegalovirus infections in kidney transplant recipients.
机译：目的：使用外周淋巴细胞的三磷酸腺苷测定可能有助于评估肾移植患者急性排斥和感染的风险。我们使用三磷酸腺苷测定来评估接受环孢素或他克莫司为基础的免疫抑制疗法的接受者之间的差异。材料和方法：在移植前后测量外周CD4 +细胞中三磷酸腺苷的水平，并将其与45位肾脏移植受者的临床结果相关。这些接受者接受了环孢素（23例）或他克莫司（22例）的免疫抑制治疗。结果：移植后2至6周，环孢霉素类治疗组的三磷酸腺苷水平明显低于他克莫司治疗组。在移植前和移植后1周之间，这些组之间的三磷酸腺苷水平相似。接受环孢霉素的接受者（17例[74％]）比他克莫司（6例[27％]; P≤.003）的巨细胞病毒感染频率更高。环孢霉素和他克莫司组的急性排斥反应发作频率相似。结论：这些观察结果表明，与基于他克莫司的治疗相比，基于环孢霉素的免疫抑制治疗会导致过度的免疫抑制，这通过淋巴细胞三磷酸腺苷水平得以证明。使用外周CD4 +细胞进行的三磷酸腺苷测定可能是预测肾移植受者巨细胞病毒感染发生的有用方法。

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