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Long-Term Consequences for Offspring of Paternal Diabetes and Metabolic Syndrome

机译：父系糖尿病和代谢综合征的后代的长期后果

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Background. Recent studies have reported an increase in the prevalence of obesity and metabolic syndrome in children and adolescents. However, few have focused how diabetes mellitus and metabolic syndrome together in parents can influence on obesity and metabolic disturbances in offspring.Objective. To know the risk obesity and metabolic disturbance in children, adolescents, and young adults whose parents have diabetes mellitus and metabolic syndrome.Methods. A comparative survey was made in healthy children of parents with diabetes mellitus and metabolic syndrome compared with offspring of healthy parents. We performed anthropometry and evaluated blood pressure, glucose, total cholesterol, HDL cholesterol, and triglycerides levels in plasma. We registered parent antecedents to diabetes mellitus and metabolic syndrome and investigated the prevalence of overweight, obesity, and metabolic disturbances in offspring.Results. We studied 259 subjects of 7 to 20 years of age. The prevalence of overweight and obesity was 27% and 37%, respectively. The highest proportion of BMI >95th of the entire group was found in offspring with both diabetic parents. Glucose and total cholesterol levels were lower in the group with healthy parents compared with the group with diabetic mother and metabolic syndrome but with healthy father. HDL cholesterol was higher in the group with both healthy parents than in the group with diabetic mother and metabolic syndrome but healthy father.Conclusions. The offspring of parents with diabetes plus metabolic syndrome showed higher proportion of variables related to metabolic syndrome compared with healthy parents.
机译：背景。最近的研究报告了儿童和青少年肥胖症和代谢综合征的患病率增加。然而，很少有人关注父母中的糖尿病和代谢综合症如何影响后代的肥胖和代谢紊乱。了解父母患有糖尿病和代谢综合征的儿童，青少年和年轻人的肥胖风险和代谢紊乱。对患有糖尿病和代谢综合征的父母的健康儿童与健康父母的后代进行了比较调查。我们进行了人体测量，并评估了血浆中的血压，葡萄糖，总胆固醇，HDL胆固醇和甘油三酸酯水平。我们注册了糖尿病和代谢综合征的父母先例，并调查了超重，肥胖和后代代谢障碍的患病率。我们研究了259位7至20岁的受试者。超重和肥胖的患病率分别为27％和37％。在两个糖尿病父母的后代中，发现BMI的比例最高，占整个组的95％。健康父母组的血糖和总胆固醇水平低于患有糖尿病母亲和代谢综合征但健康父亲的组。有健康父母的组的HDL胆固醇高于有糖尿病母亲和代谢综合症但健康的父亲的组。与健康父母相比，患有糖尿病加代谢综合症的父母的后代表现出与代谢综合症有关的变量比例更高。

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