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首页> 外文期刊>Experimental diabetes research >Acute Hyperglycemia Does Not Impair Microvascular Reactivity and Endothelial Function during Hyperinsulinemic Isoglycemic and Hyperglycemic Clamp in Type 1 Diabetic Patients
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Acute Hyperglycemia Does Not Impair Microvascular Reactivity and Endothelial Function during Hyperinsulinemic Isoglycemic and Hyperglycemic Clamp in Type 1 Diabetic Patients

机译：急性高血糖不会损害1型糖尿病患者的高胰岛素等血糖和高血糖钳夹过程中的微血管反应性和内皮功能

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Aims. The aim of this study was to evaluate the effect of acute glycemia increase on microvasculature and endothelium in Type 1 diabetes during hyperinsulinemic clamp.Patients and Methods. Sixteen patients (51±7 yrs) without complications were examined during iso- and hyperglycemic clamp (glucose increase 5.5 mmol·L−1). Insulin, lipid parameters, cell adhesion molecules and fibrinogen were analyzed. Microvascular reactivity (MVR) was measured by laser Doppler flowmetry.Results. Maximum perfusion and the velocity of perfusion increase during PORH were higher in hyperglycemia compared to baseline (47±16versus40±16 PU,P<0.01, and10.4±16.5versus2.6±1.5 PU·s−1,P<0.05, resp.). Time to the maximum perfusion during TH was shorter and velocity of perfusion increase during TH higher at hyperglycemia compared to isoglycemic phase (69±15versus77±16 s,P<0.05, and1.4±0.8versus1.2±0.7 PU·s−1,P<0.05, resp.). An inverse relationship was found between insulinemia and the time to maximum perfusion during PORH (r=−0.70,P=0.007).Conclusion. Acute glycemia did not impair microvascular reactivity in this clamp study in Type 1 diabetic patients. Our results suggest that insulin may play a significant role in the regulation of microvascular perfusion in patients with Type 1 diabetes through its vasodilation effect and can counteract the effect of acute glucose fluctuations.
机译：目的这项研究的目的是评估在高胰岛素钳夹期间急性血糖升高对1型糖尿病微血管和内皮的影响。患者和方法。在等血糖和高血糖钳制期间（葡萄糖增加5.5mmol·L-1）检查了16例无并发症的患者（51±7岁）。分析胰岛素，脂质参数，细胞粘附分子和纤维蛋白原。通过激光多普勒血流仪测量微血管反应性（MVR）。高血糖时，PORH期间最大灌注和灌注速度高于基线（47±16对40±16 PU，P <0.01，和10.4±16.5对2.6±1.5 PU·s-1，P <0.05，相对）。与同血糖阶段相比，高血糖时TH的最大灌注时间较短，TH时的灌注速度加快（69±15对77±16uss，P <0.05，和1.4±0.8对1.2±0.7 PU·s-1 ，P <0.05，分别）。胰岛素血症与PORH达到最大灌注时间之间存在反比关系（r = -0.70，P = 0.007）。结论。在这项钳位研究中，急性血糖不影响1型糖尿病患者的微血管反应性。我们的结果表明，胰岛素可能通过其血管舒张作用在1型糖尿病患者的微血管灌注调节中发挥重要作用，并且可以抵消急性葡萄糖波动的影响。

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