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首页> 外文期刊>Gene Therapy and Molecular Biology >The ETS-domain transcription factors: lessons fromthe TCF subfamily.
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The ETS-domain transcription factors: lessons fromthe TCF subfamily.

机译：ETS域转录因子：来自TCF亚科的经验教训。

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摘要

The ternary complex factors (TCFs) represent a subfamily of ETS-domain transcription factors. In recent years, several significant advances have been made in our understanding of their function at the molecular level. Many aspects of TCF function are conserved with other ETS-domain proteins and with transcription factors from other families, therefore these studies contribute more generally to our understanding of transcription factor function. Structural and biochemical studies have furthered our understanding of protein-DNA recognition by the TCFs. Furthermore, significant insights into the regulation of TCF activity by phosphorylation have been achieved. The TCFs have developed as a paradigm for nuclear targets of MAP kinase pathways and further advances have been made into understanding the specificity of kinase action towards the TCFs. The TCFs are known to bind to multiple protein partners which have roles in up- and down-regulating their activity, recruitment to DNA and transmission of transcriptional activation and repression signals. Finally, our understanding of the role of TCFs in specific biological processes is starting to become clearer, with roles defined in immediate-early gene regulation in a neuronal context.
机译：三元复合因子（TCF）代表ETS结构域转录因子的一个亚家族。近年来，在我们对它们在分子水平上的功能的理解上取得了一些重大进展。 TCF功能的许多方面与其他ETS结构域蛋白和其他家族的转录因子均是保守的，因此，这些研究更广泛地有助于我们对转录因子功能的理解。结构和生化研究进一步加深了我们对TCF对蛋白质DNA识别的了解。此外，已经获得了通过磷酸化调节TCF活性的重要见解。 TCF已发展成为MAP激酶途径核靶标的范例，并且在了解激酶针对TCF的特异性方面取得了进一步的进展。已知TCF与多种蛋白质伴侣结合，这些蛋白质伴侣在上调和下调其活性，募集到DNA以及转录激活和抑制信号的传递中具有作用。最后，我们对TCF在特定生物过程中的作用的认识开始变得更加清晰，在神经元环境中，这些作用在早期基因调控中定义。

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