Human cytomegalovirus (HCMV) nuclease:implications for new strategies in gene therapy

Dr.; Elke Bogner

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Human cytomegalovirus (HCMV) nuclease:implications for new strategies in gene therapy

机译：人类巨细胞病毒（HCMV）核酸酶：对基因治疗新策略的启示

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Human cytomegalovirus (HCMV), one of eight human herpesviruses, can cause serious illness in neonates as well as in immunocompromised adults (Alford and Britt, 1993). Transplant and AIDS patients, e.g. may develop life- threatening diseases as a consequence of primary infection or reactivation of latent infection. Additionally, HCMV infections are also associated with congenital neurological complications in approximately 7,500 newborns annually (Alford and Britt, 1993). The current drugs are toxic and cause additional complications including drug resistance. Since present therapeutical approaches are limited new strategies are needed that may result from a better understanding of viral molecular biology.

机译：人类巨细胞病毒（HCMV）是八种人类疱疹病毒之一，可在新生儿以及免疫功能低下的成年人中引起严重疾病（Alford and Britt，1993）。移植和艾滋病患者，例如初次感染或潜伏感染的重新激活可能导致威胁生命的疾病。此外，每年大约有7,500名新生儿中，HCMV感染还与先天性神经系统并发症相关（Alford和Britt，1993）。当前的药物是有毒的，并引起包括耐药性在内的其他并发症。由于目前的治疗方法是有限的，需要新的策略，这可能是由于对病毒分子生物学的更好理解而产生的。

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《Gene Therapy and Molecular Biology》 |1999年第3期|共4页
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Dr.; Elke Bogner;
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1. Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV. [J] . McGregor A, Choi KY, Schleiss MR Virology . 2011,第1期

机译：豚鼠巨细胞病毒GP84是人类巨细胞病毒（HCMV）UL84基因的功能同源物，可以补充嵌合HCMV中UL84的丢失。
2. First-line Therapy With Donor-derived Human Cytomegalovirus (HCMV)-specific T Cells Reduces Persistent HCMV Infection by Promoting Antiviral Immunity After Allogenic Stem Cell Transplantation [J] . Clinical infectious diseases . 2020,第7期

机译：具有供体衍生的人巨细胞病毒（HCMV）的一线治疗 - 特异性T细胞通过在同种异体干细胞移植后促进抗病毒免疫力来减少持续的HCMV感染
3. Effects of First-line Therapy With Donor-derived Human Cytomegalovirus (HCMV)-specific T Cells Reduces Persistent HCMV Infection by Promoting Antiviral Immunity After Allogenic Stem Cell Transplantation (vol 69, pg 2238, 2019) [J] . Zhao Xiang-Yu, Pei Xu-Ying, Chang Ying-Jun, Clinical infectious diseases . 2019,第12期

机译：与供体衍生的人巨细胞病毒（HCMV） - 特异性T细胞的效果通过促进同种异体干细胞移植后促进抗病毒免疫（Vol 69，PG 2238,2019）来减少持续的HCMV感染
4. Gain-of-function and loss-of-function analyses in vivo of transcriptional factor and cytokine genes using Epstein-Barr virus-based episomal vectors, and their implication to novel strategies of gene therapy and regenerative medicine [C] . 2010 International Symposium on Micro-NanoMechatronics and Human Science . 2010

机译：使用基于爱泼斯坦-巴尔病毒的附加型载体进行转录因子和细胞因子基因的体内功能获得和功能丧失分析，及其对基因治疗和再生医学新策略的启示
5. Gene transfer and gene expression in skeletal muscle, in vitro and in vivo and the implications for human gene therapy [D] . Roman, Mark 1994

机译：骨骼肌在体外和体内的基因转移和基因表达及其对人类基因治疗的意义
6. Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV [O] . A. McGregor, K.Y. Choi, M.R. Schleiss -1

机译：豚鼠巨细胞病毒Gp84是人巨细胞病毒的功能同源物（HCmV）UL84基因可以在嵌合HCmV补充为UL84的损失
7. Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV [O] . McGregor A., Choi K.Y., Schleiss M.R. 2011

机译：豚鼠巨细胞病毒GP84是人类巨细胞病毒（HCMV）UL84基因的功能同源物，可以补充嵌合HCMV中UL84的丢失

Human cytomegalovirus (HCMV) nuclease:implications for new strategies in gene therapy

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