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Genes and Happiness

机译：基因与幸福

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Since the discovery of the double helix, the study of brain function, in terms of both physiology and behavioral traits, has resulted in a plethora of research linking these activities to the genetic basis of neurotransmitter function. Knowledge about how genes are expressed, as well as their potential impairment due to polygenic inheritance, can shed light on predispositions to addiction and self-destructive behaviors. Genetic information derived from scientific explorations of genetic traits may have important links to understanding the basis for feelings of well-being and potentially the phenomena associated with human happiness. While non-genetic oriented research of social, political, and biological studies have addressed the impact of social and institutional environments on mass political attitudes and behaviors, there is a paucity of solid research on the interrelation and influence of genetic and environmental factors on these parameters. The separate fields of psychology and molecular biology are subject to inherent limitations that may only be resolved through collaboration across disciplines. Certainly areas relating to spirituality (“Genospirituality”) and political science are just two that are beginning to emerge as fruitful grounds for identification of specific polymorphic gene associations and may pave the way to advance a new science of human nature. We address the issue of “Nature vs. Nurture” as it relates to questions regarding the definition of happiness, its causes, and its promotion. These questions are central to understanding human nature and are emerging as an important target of research, especially in the area of nutrigenomics. The present commentary attempts to identify key “vector influences” that link genes, the brain, nutrition, and social behavior to a most desired, but misunderstood, and potentially fragile experience known as “happiness.” Specifically, we propose that successful changes in body composition/body mass index (BMI)/ percentage of body fat will increase not only positive self-image, but overall wellness that produces a state of happiness. We provide preliminary evidence that utilization of a customized dopaminergic agonist LG839 DNA directed91Blum et al: Genes and Happinessnutraceutical, significantly increased happiness in obese subjects. We detail genotypes that may play a role in determining happiness, based on current knowledge.
机译：自从发现双螺旋结构以来，就生理和行为特征而言，对脑功能的研究已导致大量研究，将这些活动与神经递质功能的遗传基础联系起来。有关基因表达方式的知识以及由于多基因遗传而引起的潜在损害，可以揭示成瘾和自我毁灭行为的易感性。从遗传特征的科学探索中获得的遗传信息可能与理解幸福感以及与人类幸福相关的现象的基础具有重要的联系。尽管社会，政治和生物学研究的非遗传导向研究解决了社会和制度环境对大众政治态度和行为的影响，但是对于遗传和环境因素对这些参数的相互影响和影响，缺乏扎实的研究。心理学和分子生物学的不同领域受到固有的局限性，只有通过跨学科的合作才能解决。当然，与灵性（“ Genospirituality”）和政治学有关的领域只是两个领域，它们开始成为鉴定特定多态基因关联的丰硕成果，并可能为发展新的人性科学铺平道路。我们处理“自然与培育”的问题，因为它涉及关于幸福的定义，其成因和促进的问题。这些问题对于理解人性至关重要，并且正在成为重要的研究目标，尤其是在营养基因组学领域。本评论试图确定将基因，大脑，营养和社会行为与最期望的但被误解的，可能是脆弱的经历（称为“幸福”）联系起来的关键“媒介影响”。具体来说，我们建议成功改变身体成分/体重指数（BMI）/身体脂肪百分比不仅会增加积极的自我形象，而且会增加产生幸福感的整体健康状况。我们提供了初步的证据，即利用定制的多巴胺能激动剂LG839 DNA指导的91Blum等人：基因和幸福营养品，显着增加了肥胖受试者的幸福感。基于当前的知识，我们详细介绍了可能在确定幸福中起作用的基因型。

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