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首页> 外文期刊>Gene Therapy and Molecular Biology >Association of Interleukin 1B -511C/T polymorphismwith Osteoarthritis, Juvenile Idiopathic Arthritis andRheumatoid Arthritis susceptibility: a meta-analysis
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Association of Interleukin 1B -511C/T polymorphismwith Osteoarthritis, Juvenile Idiopathic Arthritis andRheumatoid Arthritis susceptibility: a meta-analysis

机译：白细胞介素1B -511C / T多态性与骨关节炎，青少年特发性关节炎和类风湿关节炎易感性的关联：一项荟萃分析

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Background: A number of studies have been conducted to investigate the different types of inflammatory arthritis potential association with the IL-1B -511C/T polymorphism. However, results were inconsistent. We performed this meta-analysis to estimate the association between -511C/T polymorphism and osteoarthritis (OA), juvenile idiopathicarthritis (JIA) and rheumatoid arthritis (RA). Methods: Electronic search of PubMed and CNKI was conducted to select studies. Studies containing available genotype frequencies of -511C/T were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Results: The final meta-analysis included 17 published studies including 1447 OA cases and 1171 controls, 234 JIA cases and 313 controls, 3524 RA cases and 3111 controls separately. The results suggested that the variant genotype was associated with RA in the total population (additive model: OR 0.925, 95% CI (0.860~0.995), P = 0.035). However, the association was not significant between this polymorphism and OA (additive model: OR=1.067, 95% CI: 0.937~1.214, p= 0.328; dominant model: OR =0.930, 95% CI: 0.706~1.225, p=0.606) or JIA in the total population (additive model: OR=1.067, 95% CI: 0.821~1.338, p= 0.626; dominant model: OR =1.269, 95% CI: 0.843~1.909, p=0.254), The stratification by ethnicity failed to identify any association between this polymorphism and OA, JIA, RA in Asian, Caucasian or African groups. Conclusion: This meta-analysis suggests that the allele T of IL-1B -511C/T polymorphism is associated with decreased risk of RA in all ethnicities including Caucasian, Asian and African.
机译：背景：已经进行了许多研究，以研究与IL-1B -511C / T多态性相关的不同类型的炎症性关节炎潜能。但是，结果不一致。我们进行了这项荟萃分析，以估计-511C / T多态性与骨关节炎（OA），青少年特发性关节炎（JIA）和类风湿关节炎（RA）之间的关联。方法：对PubMed和CNKI进行电子搜索以选择研究。选择包含可用基因型频率为-511C / T的研究，并使用具有95％置信区间（CI）的合并比值比（OR）评估相关性。结果：最终的荟萃分析包括17项已发表的研究，分别包括1447例OA病例和1171例对照，234例JIA病例和313例对照，3524例RA患者和3111例对照。结果表明，变异基因型与总人群中的RA相关（加性模型：OR 0.925，95％CI（0.860〜0.995），P = 0.035）。然而，这种多态性与OA之间的关联并不显着（加性模型：OR = 1.067，95％CI：0.937〜1.214，p = 0.328;优势模型：OR = 0.930，95％CI：0.706〜1.225，p = 0.606 ）或总人口中的JIA（加性模型：OR = 1.067，95％CI：0.821〜1.338，p = 0.626;优势模型：OR = 1.269，95％CI：0.843〜1.909，p = 0.254），按种族未能识别出这种多态性与亚洲，白种人或非洲群体的OA，JIA，RA之间的任何关联。结论：这项荟萃分析表明，IL-1B -511C / T多态性等位基因T与所有种族（包括白种人，亚洲和非洲）的RA风险降低有关。

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