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首页> 外文期刊>European cytokine network >Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis
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Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis

机译：白细胞介素-10多态性与青少年特发性关节炎的易感性之间的关联：系统审查和荟萃分析

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Background: Cytokine genes, including interleukin-10 (IL-10), are knownto play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA. Methods: A meta-analysis was performed on the associations between the IL-10 -1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and 6,142 controls were considered in the meta-analysis. Results: Meta-analysis of the IL-10 -592 C/A and -819 C/T polymorphisms showed no association with JIA in the study participants, or in Caucasian or Middle Eastern participants. Meta-analysis of the IL-10 -1082 A allele in all study participants, Caucasian and Middle Eastern, showed significant associations with RA (overall ORs were 1.17, 1.15, and 1.41, respectively). Meta-analysis of the AA versus GG genotype of the IL-10 -1082 G/A polymorphism revealed significant associations with JIA (OR = 3.66, 95% CI = 1.44-9.29, P = 0.006) in participants from Middle Eastern countries. Additionally, meta-analysis of the GG versus AA+GA genotypes of the IL-10 -1082 G/A polymorphism revealed the GG genotype as the protective factor against JIA in the Middle Eastern subgroup (OR = 0.44, 95% CI = 0.20-0.94, P = 0,04). Moreover, meta-analysis of the IL-10 -1082 A allele in 4 studies on Hardy-Weinberg equilibrium showed a significant association with JIA (OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009). No association was found between the IL-10 (-1082, -819, -592) ACC, ATA, and GCC haplotypes and JIA. Conclusions: These results suggest that the IL-10 -1082 G/A polymorphism confers susceptibility to JIA.
机译：背景：众所周知，包括白细胞介素-10（IL-10），包括白细胞介素-10（IL-10）的细胞因子基因在幼年特发性关节炎（jia）的发病机制中起重要作用。本研究旨在确定IL-10多态性是否会赋予贾氏的敏感性。方法：对IL-10 -1082g / a，-592c / a和-819c / t多态性和jia之间的关联进行META分析。在META分析中考虑了涉及1,785名患者和6,142次对照的7项研究总数。结果：IL-10 -592 C / A和-819 C / T多态性的META分析显示，研究参与者或在高加索或中东参与者中没有与JIA相关联。所有研究参与者，高加索和中东地区的IL-10 -1082的META分析表现出与RA（总体或分别为1.17,11.15和1.41）的重要关联。 IL-10 -1082g / A多态性的AA与GG基因型的META分析揭示了中东国家的参与者中的jia（或= 3.66,95％CI = 1.44-9.29，P = 0.006）的显着关联。另外，GG与IL-10 -1082g / A多态性的GG与AA + GA基因型的荟萃分析揭示了GG基因型作为中东亚组（或= 0.44,95％CI = 0.20- 0.94，p = 0,04）。此外，IL-10 -1082的荟萃分析4次耐寒 - 韦伯贝格均衡研究的等位基因与贾斯（OR = 1.17,95％CI = 1.07-1.28，P = 0.0009）表现出显着的关系。 IL-10（-1082，-819，-592）ACC，ATA和GCC单倍型和贾没有任何关联。结论：这些结果表明IL-10 -1082 g / A多态性将赋予佳亚的易感性。

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