Targeting Myc function in cancer therapy

Dr. Peter J. Hurlin

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Targeting Myc function in cancer therapy

机译：靶向Myc在癌症治疗中的功能

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The development of novel therapeutic strategies to improve the survival rate of patients with cancer requires a better understanding of the critical events that underlie the origins and progression of tumors. The Myc family of transcription factors play important normal roles in regulating cell proliferation and their deregulated or elevated expression is one of the most common features of cancer cells. Here, we review mechanisms thought to underlie Myc-dependent tumor formation and discuss possible strategies for disrupting the oncogenic activity of Myc family proteins.

机译：开发新的治疗策略以提高癌症患者的生存率需要更好地了解构成肿瘤起源和进展的关键事件。 Myc转录因子家族在调节细胞增殖中起着重要的正常作用，其失调或升高的表达是癌细胞的最常见特征之一。在这里，我们审查了被认为是Myc依赖性肿瘤形成基础的机制，并讨论了破坏Myc家族蛋白致癌活性的可能策略。

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《Gene Therapy and Molecular Biology》 |2004年第7期|共8页
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Dr. Peter J. Hurlin;
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中图分类基础医学;
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2. Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer [J] . Mohamed Elbadawy, Tatsuya Usui, Hideyuki Yamawaki, International Journal of Molecular Sciences . 2019,第9期

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机译：从先进的组织工程支架中释放的基于金的治疗学的癌症靶向，成像和光热疗法的多功能。
5. Targeted Degradation of the MYC Oncogene Using PP2A-B56alpha Selective Small Molecule Modulators of Proteinphosphatase 2A as a Therapeutic Strategy for Treating Myc-Driven Cancers [D] . Farrington, Caroline C. 2020

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6. The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy [O] . Mauro Savino, Daniela Annibali, Nicoletta Carucci, 2011

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机译：Myc抑制剂被称为Omomyc的作用机制可能为如何靶向Myc进行癌症治疗提供线索

Targeting Myc function in cancer therapy

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