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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Colquhounia Root Tablet Protects Rat Pulmonary Microvascular Endothelial Cells against TNF--Induced Injury by Upregulating the Expression of Tight Junction Proteins Claudin-5 and ZO-1
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Colquhounia Root Tablet Protects Rat Pulmonary Microvascular Endothelial Cells against TNF--Induced Injury by Upregulating the Expression of Tight Junction Proteins Claudin-5 and ZO-1

机译：秋水仙根片通过上调紧密连接蛋白Claudin-5和ZO-1的表达保护大鼠肺微血管内皮细胞免受TNF诱导的损伤

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Background. There are currently limited effective pharmacotherapy agents for acute lung injury (ALI). Inflammatory response in the lungs is the main pathophysiological process of ALI. Our preliminary data have shown that colquhounia root tablet (CRT), a natural herbal medicine, alleviates the pulmonary inflammatory responses and edema in a rat model with oleic acid-induced ALI. However, the potential molecular action mechanisms underlining its protective effects against ALI are poorly understood. This study aimed to investigate the effects and mechanism of CRT in rat pulmonary microvascular endothelial cells (PMEC) with TNF-α-induced injury. Methods. PMECs were divided into 6 groups normal control, TNF-α (10?ng/mL TNF-α), Dex (1× M Dex
机译：背景。当前，针对急性肺损伤（ALI）的有效药物疗法有限。肺部的炎症反应是ALI的主要病理生理过程。我们的初步数据显示，天然草药秋水仙根片（CRT）可以减轻油酸诱导的ALI大鼠的肺部炎症反应和水肿。但是，对潜在的分子作用机制强调其对ALI的保护作用了解得很少。本研究旨在探讨CRT在TNF-α诱导的大鼠肺微血管内皮细胞（PMEC）中的作用及其机制。方法。 PMEC分为6组正常对照组：TNF-α（10？ng / mLTNF-α），Dex（1×M Dex

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