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首页> 外文期刊>Experimental & translational stroke medicine >Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke
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Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke

机译：应激诱导的糖皮质激素受体激活决定缺血性中风后的功能恢复

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Background A major consequence of stroke is permanent motor disturbance, such as postural imbalance and loss of skilled movement. The degree of neuronal and functional loss and subsequent recovery after stroke is influenced by hypothalamic-pituitary-adrenal axis activation and the response to glucocorticoid hormones. This study investigated if recovery after stroke is related to glucocorticoid receptor (GR) activation in a rat model of stroke. Methods Adult male rats were pre-trained and tested in a skilled reaching task and received a focal ischemic motor cortex lesion. One group of animals received daily restraint stress starting one week pre-lesion up to three weeks post-lesion. Immuno-histochemical analysis of GR expression was performed to determine receptor activation. Results Stress reduced reaching success in na?ve animals and diminished recovery of limb use. Exaggerated functional loss in stressed rats was related to increased GR activation in the lesion hemisphere as indicated by nuclear GR location. Conclusion These findings provide a mechanistic link between stress-induced motor disability and GR activation in a rat model of stroke. The elevated receptor activation proposes synergistic effects of stress and stroke to modulate the impact of glucocorticoids on motor system function at the genomic level. The modulation of GR biosynthesis may alter responsiveness to stroke treatment and compromise recovery.
机译：背景技术中风的主要后果是永久性的运动障碍，例如姿势不平衡和熟练运动的丧失。下丘脑-垂体-肾上腺轴激活和对糖皮质激素的反应影响中风后神经元和功能丧失的程度以及随后的恢复程度。这项研究调查了中风大鼠模型中风后的恢复是否与糖皮质激素受体（GR）激活有关。方法对成年雄性大鼠进行预训练并对其进行熟练的测试，并接受局灶性缺血性运动皮层病变。一组动物在患病前一周至患病后三周接受每日约束压力。进行了GR表达的免疫组织化学分析以确定受体激活。结果压力降低了幼稚动物的成功率，并减少了肢体使用的恢复。如核GR位置所示，在应激大鼠中夸大的功能丧失与病变半球中GR活化增加有关。结论这些发现为中风大鼠模型的应激诱发的运动障碍与GR激活之间建立了机械联系。受体活化的升高提出了压力和中风的协同作用，以调节糖皮质激素在基因组水平上对运动系统功能的影响。 GR生物合成的调节可能会改变对中风治疗的反应性并损害恢复。

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