MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

Cong-Jun Li; Robert W. Li; Theodore H. Elsasser

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MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

机译：MicroRNA（miRNA）的表达受丁酸诱导的牛细胞基因表达的表观遗传调控。

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We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly (P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly (P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism.

机译：我们目前的证据，丁酸盐诱导组蛋白乙酰化调节miRNA的表达。 MicroRNA表达微阵列分析显示，用10 mM丁酸酯处理细胞后，有35个miRNA转录物显着（P <0.05）差异表达。其中，11个转录本差异表达非常显着（P <0.01）。使用MetaCore分析套件进行的功能和途径分析表明，针对某些非常重要的基因网络的差异表达miRNA和差异表达miRNA可能会干扰丁酸酯诱导的基因表达和细胞功能调节。数据表明，miRNA与组蛋白乙酰化之间复杂的相互作用形成了高度集成的调节机制。

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《Genetics & Epigenetics》 |2010年第3期|共10页
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Cong-Jun Li; Robert W. Li; Theodore H. Elsasser;
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中图分类遗传学;
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6. Novel expression profiles of microRNAs suggest that specific miRNAs regulate gene expression for the sexual maturation of female Schistosoma japonicum after pairing [O] . Jun Sun, Suwen Wang, Chen Li, 2014

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7. MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells [O] . Cong-Jun Li, Robert W. Li, Theodore H. Elsasser 2010

机译：微小RNa（miRNa）表达受丁酸盐诱导的牛细胞基因表达的表观遗传调控调控

MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

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