...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes and Nutrition >The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level
【24h】

The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level

机译：分子营养研究的挑战3：比较营养学研究作为进入系统水平的基础

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human nutrition and metabolism may serve as the paradigm for the complex interplay of the genome with its environment. The concept of nutrigenomics now enables science with new tools and comprehensive analytical techniques to investigate this interaction at all levels of the complexity of the organism. Moreover, nutrigenomics seeks to better define the homeostatic control mechanisms, identify the de-regulation in the early phases of diet-related diseases, and attempts to assess to what extent an individual‘s sensitizing genotype contributes to the overall health or disease state. In a comparative approach nutrigenomics uses biological systems of increasing complexity from yeast to mammalian models to define the general rules of metabolic and genetic mechanisms in adaptations to the nutritional environment. Powerful information technology, bioinformatics and knowledge management tools as well as new mathematical and computational approaches now make it possible to study these molecular mechanisms at the cellular, organ and whole organism level and take it on to modeling the processes in a “systems biology” approach. This review summarizes some of the concepts of a comparative approach to nutrigenomics research, identifies current lacks and proposes a concerted scientific effort to create the basis for nutritional systems biology.
机译：人类的营养和代谢可能是基因组与其环境之间复杂相互作用的范例。营养基因组学的概念现在使科学能够使用新的工具和全面的分析技术来研究有机物复杂性各个层面的相互作用。此外，营养人体工程学试图更好地定义稳态控制机制，识别饮食相关疾病早期阶段的放松调节，并试图评估个体的致敏基因型在多大程度上有助于整体健康或疾病状态。在一种比较方法中，营养基因组学使用从酵母到哺乳动物模型越来越复杂的生物系统来定义适应营养环境的代谢和遗传机制的一般规则。强大的信息技术，生物信息学和知识管理工具以及新的数学和计算方法现在使在细胞，器官和整个生物体水平上研究这些分子机制成为可能，并以“系统生物学”方法对过程进行建模。 。这篇综述总结了营养学研究比较方法的一些概念，发现了目前的不足，并提出了协调一致的科学努力来为营养系统生物学奠定基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号