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首页> 外文期刊>Genes and Nutrition >Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro
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Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

机译：筛选韩国药用植物的体外破骨作用

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Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKL-induced osteoclast differentiation.
机译：骨骼通过骨骼的形成和吸收而不断进行重塑，并保持骨骼刚度的平衡。骨吸收和丢失通常归因于破骨细胞。破骨细胞的分化受肿瘤坏死因子家族成员核因子NF-kB配体（RANKL）受体激活剂的调控。当平衡受到干扰时，就会发生病理性骨骼异常。通过筛选韩国传统药用植物，确定了抑制和刺激小鼠骨髓巨噬细胞中RANKL诱导的破骨细胞分化的有效分子。在药用植物的222种甲醇提取物中，有10个样品表现出诱导破骨细胞分化的能力。这些包括Dryobalanopsaromatica，Euphoria longana，Lithospermum erythrorhizon，Prunus mume，Prunus nakaii和玉竹。相比之下，臭椿，姜黄，龙葵，蒲公英，cho藜，Da粉虱对RANKL诱导的破骨细胞分化具有抑制作用。

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