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首页> 外文期刊>Genome Integrity >Assessment of correlation between chromosomal radiosensitivity of peripheral blood lymphocytes after In vitro irradiation and normal tissue side effects for cancer patients undergoing radiotherapy
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Assessment of correlation between chromosomal radiosensitivity of peripheral blood lymphocytes after In vitro irradiation and normal tissue side effects for cancer patients undergoing radiotherapy

机译：癌症患者放射治疗后外周血淋巴细胞染色体放射敏感性与正常组织副作用之间的相关性评估

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Patients receiving identical radiation treatments experience different effects, from undetectable to severe, on normal tissues. A crucial factor of radiotherapy related side effects is individual radiosensitivity. It is difficult to spare surrounding normal tissues delivering radiation to cancer cells during radiotherapy. Therefore, it may be useful to develop a simple routine cytogenetic assay which would allow the screening of a large number of individuals for radiosensitivity optimizing tumor control rates and minimizing severe radiotherapy effects with possibility to predict risk level for developing more severe early normal tissue adverse events after irradiation. This study was conducted to assess the correlation between in vitro radiosensitivity of peripheral blood lymphocytes from cancer patients who are undergoing radiotherapy using the cytokinesis-block micronucleus (CBMN), G2 chromosomal radiosensitivity assays, and normal tissue acute side effects. The CBMN and G2 chromosomal radiosensitivity assays were performed on blood samples taken from cancer patients before radiotherapy, after first fractionation, and after radiotherapy. Acute normal tissue reactions were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer. This study suggests that there is a correlation between higher frequency of micronuclei after in vitro irradiation of blood samples and higher degree of normal tissue reactions. In addition, higher number of chromatid breaks was observed in patients with more severe normal tissue reactions. This pilot study included only 5 cancer patients, and therefore, further studies with a bigger cohort are required to identify radiosensitive patients.
机译：接受相同放射治疗的患者对正常组织有不同的影响，从无法检测到严重。放射治疗相关副作用的关键因素是个体放射敏感性。在放射治疗期间很难保留周围的正常组织，从而将辐射传递给癌细胞。因此，开发一种简单的常规细胞遗传学测定方法可能是有用的，该方法将允许筛查大量个体以进行放射敏感性优化肿瘤控​​制率并使严重的放射治疗效果最小化，并有可能预测发生更严重的早期正常组织不良事件的风险水平照射后。这项研究的目的是评估使用细胞分裂阻滞微核（CBMN）进行放射治疗的癌症患者的外周血淋巴细胞的体外放射敏感性，G2染色体放射敏感性测定与正常组织急性副作用之间的相关性。 CBMN和G2染色体放射敏感性测定是在放疗前，第一次分级分离和放疗后对癌症患者的血液样本进行的。急性正常组织反应根据放射治疗肿瘤学小组/欧洲癌症研究和治疗组织进行分级。这项研究表明，在体外照射血液样本后，更高的微核频率与更高水平的正常组织反应之间存在相关性。此外，在正常组织反应较严重的患者中观察到了更多的染色单体断裂。这项前瞻性研究仅包括5名癌症患者，因此，需要更多的队列研究来确定放射敏感性患者。

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