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首页> 外文期刊>Genome Integrity >Enhancing cytogenetic biological dosimetry capabilities of the philippines for nuclear incident preparedness
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Enhancing cytogenetic biological dosimetry capabilities of the philippines for nuclear incident preparedness

机译：增强菲律宾进行核事故准备的细胞遗传学生物剂量学能力

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The utility of a biological dosimeter based on the analysis of dicentrics is invaluable in the event of a radiological emergency wherein the estimated absorbed dose of an exposed individual is crucial in the proper medical management of patients. The technique is also used for routine monitoring of occupationally exposed workers to determine radiation exposure. An in vitro irradiation study of human peripheral blood lymphocytes was conducted to establish a dose-response curve for radiation-induced dicentric aberrations. Blood samples were collected from volunteer donors and together with optically stimulated luminescence (OSL) dosimeters and were irradiated at 0, 0.1, 0.25, 0.5, 0.75, 1, 2, 4, and 6 Gy using a cobalt-60 radiotherapy unit. Blood samples were cultured for 48 h, and the metaphase chromosomes were prepared following the procedure of the International Atomic Energy Agency's Emergency Preparedness and Response – Biodosimetry 2011 manual. At least 100 metaphases were scored for dicentric aberrations at each dose point. The data were analyzed using R language program. The results indicated that the distribution of dicentric cells followed a Poisson distribution and the dose-response curve was established using the estimated model, Ydic = 0.0003 (±0.0003) +0.0336 (±0.0115) × D + 0.0236 (±0.0054) × D2. In this study, the reliability of the dose-response curve in estimating the absorbed dose was also validated for 2 and 4 Gy using OSL dosimeters. The data were fitted into the constructed curve. The result of the validation study showed that the obtained estimate for the absorbed exposure doses was close to the true exposure doses.
机译：在放射紧急情况下，基于双着丝粒分析的生物剂量计的实用性是无价的，在这种情况下，暴露个体的估计吸收剂量对于患者的正确医疗管理至关重要。该技术还用于对受职业暴露的工人进行例行监测以确定辐射暴露。进行了人类外周血淋巴细胞的体外辐射研究，以建立辐射诱发的双中心像差的剂量反应曲线。从志愿者供体中收集血液样本，并与光激发发光（OSL）剂量计一起使用60钴放射治疗仪以0、0.1、0.25、0.5、0.75、1、2、4和6 Gy照射。将血样培养48小时，并按照国际原子能机构《 2011年紧急准备和响应–生物剂量测定》手册的程序制备中期染色体。在每个剂量点对至少100个中期进行了双中心像差评分。使用R语言程序分析数据。结果表明，双中心细胞的分布遵循泊松分布，并使用估计模型建立剂量反应曲线，Y dic = 0.0003（±0.0003）+0.0336（±0.0115）×D + 0.0236（±0.0054）×D 2 。在这项研究中，使用OSL剂量计还验证了2 Gy和4 Gy剂量反应曲线在估计吸收剂量方面的可靠性。将数据拟合到构建的曲线中。验证研究的结果表明，所获得的吸收暴露剂量估算值接近于真实暴露剂量。

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