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首页> 外文期刊>Genetics and Molecular Research >Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population
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Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

机译:基质金属蛋白酶9 rs3918242多态性与中国人群冠状动脉疾病发展的关系

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We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had higher systolic and diastolic blood pressure, as well as higher triglycerides (P MMP-9 rs3918242 polymorphism is correlated with an increased risk of coronary artery disease in a Chinese population.
机译:我们进行了一项病例对照研究,以研究MMP-9 rs3918242的一个单核苷酸多态性在冠心病发展中的作用。 rs3918242使用聚合酶链反应与限制性片段长度多态性结合,用435-bp DNA片段扩增。与对照组相比,冠心病患者的收缩压和舒张压更高,甘油三酸酯含量更高(P MMP-9 rs3918242多态性与中国人群冠心病风险增加相关)。

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