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Multiple Testing in the Context of Gene Discovery in Sickle Cell Disease Using Genome-Wide Association Studies:

机译:在镰状细胞病的基因发现背景下,使用全基因组关联研究进行多重测试:

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The issue of multiple testing, also termed multiplicity, is ubiquitous in studies where multiple hypotheses are tested simultaneously. Genome-wide association study (GWAS), a type of genetic association study that has gained popularity in the past decade, is most susceptible to the issue of multiple testing. Different methodologies have been employed to address the issue of multiple testing in GWAS. The purpose of the review is to examine the methodologies employed in dealing with multiple testing in the context of gene discovery using GWAS in sickle cell disease complications.
机译:多重检验(也称为多重性)的问题在同时检验多个假设的研究中无处不在。全基因组关联研究(GWAS)是在过去十年中广受欢迎的一种遗传关联研究,最容易受到多重测试问题的影响。已经采用了不同的方法来解决GWAS中的多重测试问题。审查的目的是检查在镰状细胞疾病并发症中使用GWAS进行基因发现的背景下进行多重检测的方法。

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