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Influence of epistatic segregation distortion loci on genetic marker linkages in Japanese flounder

机译：上位偏析畸变基因座对日本比目鱼遗传标记连锁的影响

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For genetic linkage analysis of Japanese flounder, 160 doubled haploids (DH) were artificially produced using mitotic gynogenesis and were genotyped for 458 simple sequence repeat (SSR) markers, 101 of which show distortional segregation. The genetic linkage map was constructed by modifying recombination fractions between the distorted markers. Between the corrected and uncorrected genetic maps, there were considerable differences in genetic distance, but not in relative locations among markers. Using a liability model, a segregation distortion locus (SDL), with an additive genetic effect of 1.772, was mapped between markers BDHYP387 and Poli56TUF of chromosome 24 in the corrected genetic map. Additionally, six pairs of epistatic SDLs were identified on chromosomes 1, 5, 8, 9, 23, and 24. Changes in genetic distances between markers did not occur on chromosome regions with main effect SDLs. However, most chromosome regions where genetic distances changed covered the detected epistatic SDLs. This study concluded that epistatic SDLs decrease linkages between markers and lengthen genetic distances in Japanese flounder. This finding has been partially validated in other DH populations derived from three female Japanese flounders.
机译：为了对日本比目鱼进行遗传连锁分析，使用有丝分裂的雌核发育过程人工生产了160个双倍单倍体（DH），并对其进行了458个简单序列重复（SSR）标记的基因分型，其中101个显示畸变分离。遗传连锁图谱是通过修饰扭曲的标记之间的重组比例而构建的。在校正和未校正的遗传图谱之间，遗传距离存在相当大的差异，但标记之间的相对位置没有差异。使用责任模型，在校正后的遗传图谱中，在24号染色体的标记BDHYP387和Poli56TUF之间绘制了具有1.772的加成遗传效应的分离畸变基因座（SDL）。此外，在染色体1、5、8、9、23和24上鉴定出六对上位SDL。在具有主要作用SDL的染色体区域上，标记之间的遗传距离没有发生变化。但是，遗传距离发生变化的大多数染色体区域都覆盖了检测到的上位SDL。这项研究得出结论，上位性SDL减少了日本比目鱼标记之间的联系并延长了遗传距离。这一发现已在源自三只日本比目鱼的其他DH种群中得到了部分验证。

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