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Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

机译:溶菌多糖单加氧酶:结晶学家对新型生物质降解酶的看法

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Lytic polysaccharide monooxygenases (LPMOs) are a new class of microbial copper enzymes involved in the degradation of recalcitrant polysaccharides. They have only been discovered and characterized in the last 5–10 years and have stimulated strong interest both in biotechnology and in bioinorganic chemistry. In biotechnology, the hope is that these enzymes will finally help to make enzymatic biomass conversion, especially of lignocellulosic plant waste, economically attractive. Here, the role of LPMOs is likely to be in attacking bonds that are not accessible to other enzymes. LPMOs have attracted enormous interest since their discovery. The emphasis in this review is on the past and present contribution of crystallographic studies as a guide to functional understanding, with a final look towards the future.
机译:溶菌多糖单加氧酶(LPMOs)是一类新的微生物铜酶,参与难降解多糖的降解。它们仅在最近的5-10年中被发现和表征,并引起了人们对生物技术和生物无机化学的浓厚兴趣。在生物技术中,希望这些酶最终将有助于使酶促生物质转化,特别是木质纤维素植物废料的酶促生物质转化在经济上具有吸引力。此处,LPMO的作用可能是攻击其他酶无法接近的键。自发现以来,LPMO引起了极大的兴趣。这篇综述的重点是晶体学研究的过去和现在的贡献,作为对功能性理解的指南,并展望了未来。

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