• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>IUCrJ >X-ray scanning microscopies of microcalcifications in abdominal aortic and popliteal artery aneurysms
【24h】

X-ray scanning microscopies of microcalcifications in abdominal aortic and popliteal artery aneurysms

机译：腹部主动脉和pop动脉动脉瘤的微钙化的X射线扫描显微镜检查

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abdominal aortic and popliteal artery aneurysms are vascular diseases which show massive degeneration, weakening of the vascular wall and loss of the vascular tissue functionality. They are driven by inflammatory, hemodynamical factors and biological alterations that may lead, in the case of an abdominal aortic aneurysm, to sudden and dangerous ruptures of the arteries. Here, human aortic and popliteal aneurysm tissues were obtained during surgical repair, and studied by synchrotron radiation X-ray scanning microdiffraction and small-angle scattering, to investigate the microcalcifications present in the tissues. Data collected during the experiments were transformed into quantitative microscopy images through the combination of statistical approaches and crystallographic methods. As a result of this multi-step analysis, microcalcifications, which are markers of the pathology, were classified in terms of chemical and structural content. This analysis helped to identify the presence of nanocrystalline hy­droxy­apatite and microcrystalline cholesterol, embedded in myofilament, and elastin-containing tissue with low collagen content in predominantly nanocrystalline areas. The generality of the approach allows it to be transferred to other types of tissue and other pathologies affected by microcalcifications, such as thyroid carcinoma, breast cancer, testicular microli­thia­sis or glioblastoma.
机译：腹主动脉和pop动脉动脉瘤是血管性疾病，表现出大量变性，血管壁变弱和血管组织功能丧失。它们是由炎症，血液动力学因素和生物学改变驱动的，在腹主动脉瘤的情况下，可能导致动脉突然和危险的破裂。在这里，在手术修复过程中获得了人的主动脉和repair动脉瘤组织，并通过同步辐射X射线扫描微衍射和小角度散射进行了研究，以研究组织中存在的微钙化。通过统计方法和晶体学方法的结合，将实验期间收集的数据转换为定量显微镜图像。作为多步分析的结果，微钙化是病理学的标志，根据化学和结构含量进行分类。这项分析有助于确定存在于肌丝中的纳米晶羟基磷灰石和微晶胆固醇的存在，以及主要位于纳米晶区域的胶原蛋白含量低的弹性蛋白组织。该方法的通用性使其可以转移到受微钙化影响的其他类型的组织和其他病理学中，例如甲状腺癌，乳腺癌，睾丸微石症或成胶质细胞瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号