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Clinical trials in low and middle-income countries — Successes and challenges

机译:中低收入国家的临床试验-成功与挑战

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Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea. In this article we describe the challenges involved in initiating clinical trials in LMICs, review current efforts within surgical, medical, and radiation oncology, and introduce high priority topics for future research. Highlights ? Details challenges associated with conducting clinical trials in low- and middle-income countries (LMICs) ? Features examples of successful clinical trials in gynecological malignancies in LMICs ? Highlights high priority areas for continued clinical research and clinical trials in LMICs.
机译:与低收入国家(HIC)相比,妇科恶性肿瘤对中低收入国家(LMIC)的妇女造成的影响相等或更高,但是,基于在HIC中进行的临床试验的实践指南通常不能解释这些地区之间的资源差异。在LMIC中进行临床试验的需求和日益增长的兴趣。这导致了跨国合作组织的建立,并在墨西哥,中国和韩国启动了一些正在进行的临床试验。在本文中,我们描述了在LMIC中开展临床试验所面临的挑战,回顾了外科,医学和放射肿瘤学当前的工作,并介绍了未来研究的高度优先主题。强调 ?详细说明在中低收入国家(LMIC)进行临床试验所面临的挑战?中低收入国家妇科恶性肿瘤成功临床试验的特色实例?突出了在LMIC中继续进行临床研究和临床试验的高度优先领域。

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