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首页> 外文期刊>Gynecologic Oncology Reports >Using gene expression in patients with endometrial intraepithelial neoplasia to assess the risk of cancer
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Using gene expression in patients with endometrial intraepithelial neoplasia to assess the risk of cancer

机译：利用基因表达在子宫内膜上皮内瘤形成患者中评估癌症风险

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Patients diagnosed with an endometrial cancer precursor lesion on biopsy may be found to have endometrial cancer at the time of subsequent surgery. The current study seeks to identify patients with endometrial intraepithelial neoplasia (EIN) on biopsy that may be harboring an occult carcinoma. Immunohistochemical stains for gene loss of expression (LOE) for 6 genes, PTEN, ARID1A, MSH6, MSH2, MLH1, and PMS2, were performed on 113 biopsy specimens with EIN. For the 95 patients with follow-up histology, 40 patients had cancer, 41 had EIN, and 14 had normal endometrium. PTEN LOE was found frequently in both EIN and endometrial cancer, and therefore had low positive predictive value. All specimens with ARID1A, MSH6, MSH2, MLH1, or PMS2 LOE on biopsy were subsequently found to have cancer. LOE of any gene was associated with modest sensitivity (0.78) in identifying patients with endometrial cancer who had EIN on biopsy. Further investigation is warranted to determine if gene LOE is a useful clinical tool when evaluating patients with EIN on biopsy. Highlights ? PTEN, ARID1A, MSH6, MSH2, MLH1, and PMS2 were analyzed on patients with EIN. ? Loss of expression was associated with the subsequent finding of endometrial cancer. ? Sensitivity was 0.78 for loss of expression of any gene and the finding of cancer.
机译：在活检中被诊断为子宫内膜癌前体病变的患者可能在随后的手术时被发现患有子宫内膜癌。当前的研究旨在确定活检可能患有隐匿性癌的子宫内膜上皮内瘤样变（EIN）患者。对113个具有EIN的活检标本进行了6个基因（PTEN，ARID1A，MSH6，MSH2，MLH1和PMS2）的基因表达缺失（LOE）的免疫组织化学染色。在95例接受随访组织学检查的患者中，40例患有癌症，41例患有EIN，14例子宫内膜正常。在EIN和子宫内​​膜癌中均频繁发现PTEN LOE，因此其阳性预测价值较低。随后发现所有在活检中具有ARID1A，MSH6，MSH2，MLH1或PMS2 LOE的标本都患有癌症。任何基因的LOE与确定活检EIN的子宫内膜癌患者的中等敏感性（0.78）相关。有必要进行进一步的研究以确定在评估活检EIN患者时基因LOE是否是有用的临床工具。强调 ？对EIN患者进行了PTEN，ARID1A，MSH6，MSH2，MLH1和PMS2分析。 ？表达的丧失与子宫内膜癌的随后发现有关。 ？对于任何基因的表达丧失和发现癌症的敏感性为0.78。

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