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Oncofertility in the setting of advanced cervical cancer - A case report

机译：晚期宫颈癌患者的肿瘤不育-病例报告

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Objective To consider fertility options in women with advanced cervical cancer. Design Case report. Setting Large tertiary care center. Patient A 30-year-old nulligravida woman diagnosed with FIGO Stage IB I squamous cell carcinoma of the cervix that had metastasized to a pelvic lymph node. Interventions Robotic radical trachelectomy with pelvic lymphadenectomy and cerclage placement, followed by ovarian stimulation with oocyte retrieval and in vitro fertilization. Subsequent therapy included adjuvant chemoradiation and embryo transfer to a surrogate mother. Main outcome measures Cervical cancer remission, live birth from surrogate pregnancy. Results 33-year-old woman in her third year of remission from advanced cervical cancer with healthy twin girls. Conclusions Fertility options may exist for patients even in the setting of metastatic cervical cancer. Early involvement of a reproductive endocrinologist is imperative. This case emphasizes the importance of cross-specialty communication. Highlights ? Approximately 40% of women diagnosed with cervical cancer are under the age of 45. ? Fertility sparing treatment options should be considered when appropriate. ? We present a case of preserved fertility in a patient with advanced cervical cancer. ? Radical trachelectomy is as a viable option for those desiring childbearing. ? Early involvement of a reproductive endocrinologist is imperative in these cases.
机译：目的探讨晚期宫颈癌妇女的生育选择。设计案例报告。设置大型三级护理中心。患者一名30岁的无引力孕妇被诊断患有FIGO的IB I期宫颈鳞状细胞癌，并已转移至盆腔淋巴结。干预机器人根治性气管切除术联合盆腔淋巴结清扫术和环扎术，然后通过卵母细胞取回和体外受精刺激卵巢。随后的治疗包括辅助化学放疗和将胚胎转移至代孕母亲。主要预后指标宫颈癌的缓解，代孕的活产。结果33岁的妇女在她患有晚期宫颈癌的第三年与健康的双胞胎女孩一起缓解。结论即使在转移性宫颈癌的情况下，患者也可能有生育选择。生殖内分泌学家必须尽早介入。这个案例强调了跨专业交流的重要性。强调 ？被诊断患有宫颈癌的女性中，大约40％在45岁以下。适当时应考虑保留生育措施。 ？我们介绍了晚期宫颈癌患者保留生育力的情况。 ？对于希望生育的人，根治性气管切开术是可行的选择。 ？在这些情况下，必须让生殖内分泌学家及早介入。

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