Which is the best model of study of the Alzheimer’s disease?

Gonzalo Emiliano Aranda-Abreu; Maria Elena Hernandez; Luis Isauro Garcia

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Which is the best model of study of the Alzheimer’s disease?

机译：哪个是研究阿尔茨海默氏病的最佳模式？

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A problematic in the study of Alzheimer's disease is the lack of a good model that allows us either in vivo or in vitro to understand how the disease initiates. So far, the proposed models are mainly transgenic mice or rats, however, along their lifetime they do not present all the features of this disease and cell cultures present this same problematic. Thus, we have felt the need to define Alzheimer’s disease in acceptable models able to present all the characteristic events taking place in the pathogenesis of Alzheimer’s that until now we can only observe in postmortem analysis.

机译：阿尔茨海默氏病研究中的一个问题是缺少一个好的模型，该模型无法让我们在体内或体外了解疾病的起因。到目前为止，提出的模型主要是转基因小鼠或大鼠，但是，在它们的一生中，它们并没有表现出这种疾病的所有特征，而细胞培养也存在同样的问题。因此，我们感到有必要在可接受的模型中定义阿尔茨海默氏病，以呈现出阿尔茨海默氏病发病机理中发生的所有特征性事件，直到现在我们只能在死后分析中观察到。

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《eNeurobiologia》 |2010年第1期|共页
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Gonzalo Emiliano Aranda-Abreu; Maria Elena Hernandez; Luis Isauro Garcia;
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中图分类神经病学与精神病学;
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3. Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019) [J] . Yifei Lu, Zhongyuan Guo, Yujie Zhang, Advanced Science . 2019,第4期

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Which is the best model of study of the Alzheimer’s disease?

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