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首页> 外文期刊>eNeurologicalSci >Acute ischemic stroke associated with nephrotic syndrome: Incidence and significance — Retrospective cohort study
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Acute ischemic stroke associated with nephrotic syndrome: Incidence and significance — Retrospective cohort study

机译：与肾病综合征相关的急性缺血性中风：发生率和意义—回顾性队列研究

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We report 10 cases with arterial ischemic stroke (AIS) with nephrotic syndrome (NS), and clarified its incidence and clinical characteristics. The patients having albumin less than 3.0g/dl and serum cholesterol greater than 250mg/dl at the same time were retrospectively screened from 11,161 cases of stroke. Furthermore, the patients of AIS showing heavy proteinuria were selected. The 10 cases were diagnosed as AIS with NS. Its incidence was 0.09% of all kinds of stroke and 0.12% of AIS. Their subtypes were 6 large-artery atherosclerosis, 3 small-vessel occlusion, and 1 cardioembolism. We carried out a retrospective cohort study to assess the association between NS and atherosclerosis progression in AIS patients. Seven AIS patients with NS due to diabetic nephropathy (cases; NS group) were compared with patients with AIS and diabetes mellitus (DM) without NS (control group). Control group subjects were matched in a 2:1 ratio to cases by age, sex, use of medications for DM, and hemoglobin A1c (HbA1c) level. The NS group had high cerebral artery atherosclerosis scores, especially in the anterior circulation. The NS group demonstrated atherosclerosis of the internal carotid and lower extremity arteries, although there were no statistical differences between the two groups. Study subjects had high serum fibrinogen and D-dimer levels, suggesting that AIS patients with NS have a greater degree of hypercoagulability than AIS patients without NS. Highlights ? We report 10 cases with arterial ischemic stroke (AIS) with nephrotic syndrome (NS). ? The incidence AIS with NS was clarified. ? By a retrospective cohort study, AIS with NS showed atherosclerosis progression comparing the controls. ? AIS patients with NS have a greater degree of hypercoagulability than AIS patients without NS.
机译：我们报告10例肾病综合征（NS）的动脉缺血性卒中（AIS），并阐明其发病率和临床特征。从11,161例中风患者中回顾性筛选出白蛋白低于3.0g / dl且血清胆固醇高于250mg / dl的患者。此外，选择显示出重蛋白尿的AIS患者。这10例被诊断为NS伴AIS。其发生率是各种卒中的0.09％和AIS的0.12％。它们的亚型为6个大动脉粥样硬化，3个小血管闭塞和1个心脏栓塞。我们进行了一项回顾性队列研究，以评估AIS患者中NS与动脉粥样硬化进展之间的关联。将7例因糖尿病肾病引起的NS合并AIS的患者（病例; NS组）与未合并NS的AIS和糖尿病（DM）的患者（对照组）进行比较。对照组受试者按年龄，性别，DM用药和血红蛋白A1c（HbA1c）水平与病例以2：1的比例匹配。 NS组脑动脉粥样硬化评分较高，尤其是在前循环中。 NS组表现出颈内动脉和下肢动脉的动脉粥样硬化，尽管两组之间没有统计学差异。研究对象的血清纤维蛋白原和D-二聚体水平较高，表明患有NS的AIS患者比没有NS的AIS患者具有更高的高凝性。强调 ？我们报告10例肾病综合征（NS）的动脉缺血性卒中（AIS）。 ？明确了NS患者的AIS发生率。 ？通过一项回顾性队列研究，与对照组相比，AIS和NS表现出动脉粥样硬化进展。 ？患有NS的AIS患者比没有NS的AIS患者具有更高的高凝能力。

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